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ARL6IP1 / ARMER

ADP-ribosylation factor-like 6 interacting protein 1

Apoptosis is important for normal development and tissue homeostasis. It is mediated by various caspases and ultimately results in the activation of endogenous endonucleases that degrade cellular DNA. Although apoptosis induced by endoplasmic reticulum (ER) stress is thought to be mediated by caspase-12, other caspases such as caspase-9 are also thought to be activated following ER stress. Recently, ARMER, a novel integral ER-membrane protein was shown to protect cells from ER stress-induced apoptosis. Analysis of the caspase proteolytic cascade suggests that ARMER acts by inhibiting caspase-9 activity (3), although the mechanism for this remains unkown. It should be noted that ARMER is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.

Gene Name: ADP-ribosylation factor-like 6 interacting protein 1
Family/Subfamily: Apoptosis , Not assigned-Other
Synonyms: ARL6IP1, AIP1, ARL-6-interacting protein 1, ARL6IP, ARMER, AIP-1, KIAA0069
Target Sequences: NM_015161 NP_055976.1 Q15041

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Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
ARL6IP1 / ARMER (4)
No (4)
GST (1)
Myc-DDK (Flag) (3)
Human (3)
293T Cells (1)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (1)
ARL6IP1 / ARMER Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
23.2 kDa
100 µg/$494
ARL6IP1 / ARMER Protein - 12.5% SDS-PAGE of human ARL6IP stained with Coomassie Blue
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Wheat Germ Extract
GST
48.07 kDa
10 µg/$479; 25 µg/$670
ARL6IP1 / ARMER Protein - Purified recombinant protein ARL6IP1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
23.2 kDa
20 µg/$1,107
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293T Cells
Myc-DDK (Flag)
23.2 kDa
20 µg/$150
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).