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ARNTL / BMAL1
aryl hydrocarbon receptor nuclear translocator-like
ARNTL / BMAL1 is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | aryl hydrocarbon receptor nuclear translocator-like |
| Synonyms: | ARNTL, BHLH-PAS protein JAP3, BHLHe5, BMAL1c, JAP3, PASD3, Member of PAS protein 3, MOP3, TIC, Brain and muscle ARNT-like 1, Member of PAS superfamily 3 |
| Target Sequences: | NM_001178 NP_001169.3 O00327 |
Publications (5)
1
Proxisome proliferator-activated receptor- mediates high-fat, diet-enhanced daily oscillation of plasminogen activator inhibitor-1 activity in mice. Hayashida S, Kuramoto Y, Koyanagi S, Oishi K, Fujiki J, Matsunaga N, Ikeda E, Ohdo S, Shimeno H, Soeda S. Chronobiology international. 2010 27:1735-53. (WB, ChrIP; Mouse)
[PubMed:20969520]
2
Formation of invadopodia-like structures by synovial cells promotes cartilage breakdown in collagen-induced arthritis: involvement of the protein tyrosine kinase Src. Lauzier A, Charbonneau M, Harper K, Jilaveanu-Pelmus M, Dubois CM. Arthritis and rheumatism. 2011 63:1591-602. (ICC; Rat)
[PubMed:21337539]
3
Dietary proanthocyanidins modulate BMAL1 acetylation, Nampt expression and NAD levels in rat liver. Ribas-Latre A, Baselga-Escudero L, Casanova E, Arola-Arnal A, Salvadó MJ, Bladé C, Arola L. Scientific reports. 2015 5:10954. (WB; Human)
[Full Text Article]
[PubMed:26051626]
[PMC:PMC4603780]
Related Antibodies: LS-C16603.
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ARNTL / BMAL1
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acetylation site of K538.
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(1)
ARNTL / BMAL1 Mouse anti-Human Monoclonal (1C5) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
ARNTL / BMAL1 Mouse anti-Human Monoclonal (1C11) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$485
ARNTL / BMAL1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µl/$801
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$783
ARNTL / BMAL1 Rabbit anti-Human Polyclonal (aa44-91) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$397
ARNTL / BMAL1 Rabbit anti-Mouse Polyclonal (aa31-80) Antibody
Mouse
WB
Unconjugated
100 µl/$397
ARNTL / BMAL1 Rabbit anti-Human Polyclonal (aa294-624) Antibody
Human
ChrIP, IHC, IHC-P, WB
Unconjugated
50 µl/$460
ARNTL / BMAL1 Mouse anti-Human Monoclonal (Carrier-free) (1C11) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$730
Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$792
HEK 293 Cells
Myc-DDK (Flag)
64 kDa
20 µg/$1,107
ARNTL / BMAL1 Mouse anti-Human Monoclonal (OTI1H6) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
ARNTL / BMAL1 Mouse anti-Human Monoclonal (Carrier-free) (OTI1H6) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
ARNTL / BMAL1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$832
ARNTL / BMAL1 Rabbit anti-Human Polyclonal (acetylation site of K538.) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ARNTL / BMAL1 Rabbit anti-Drosophila Polyclonal Antibody
Drosophila
ELISA, WB
Unconjugated
50 µg/$832
ARNTL / BMAL1 Goat anti-Human Polyclonal (aa396-410) Antibody
Xenopus, Chicken, Sheep, Bovine, Rat, Hamster, Pig, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$503
ARNTL / BMAL1 Mouse anti-Human Monoclonal (OTI3G9) Antibody
Flo, IF, WB
Unconjugated
100 µl/$434
ARNTL / BMAL1 Mouse anti-Human Monoclonal (Carrier-free) (OTI3G9) Antibody
Dog, Rat, Human
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$511
ARNTL / BMAL1 Mouse anti-Human Monoclonal (OTI1D1) Antibody
Flo, IF, WB
Unconjugated
100 µl/$434
ARNTL / BMAL1 Mouse anti-Human Monoclonal (Carrier-free) (OTI1D1) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$748
ARNTL / BMAL1 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
ARNTL / BMAL1 Rabbit anti-Human Polyclonal (C-Terminus) (DY650) Antibody
Human
IHC, IHC-P, WB
DY650 Conjugated
0.1 ml/$416
ARNTL / BMAL1 Rabbit anti-Human Polyclonal (C-Terminus) (DY550) Antibody
Human
IHC, IHC-P, WB
DY550 Conjugated
0.1 ml/$416
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