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ARRB2 / Beta Arrestin 2

arrestin, beta 2

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Name: arrestin, beta 2
Synonyms: ARRB2, Arrestin 3, Arrestin beta-2, ARB2, ARR2, BARR2, Arrestin, beta 2, Beta-arrestin-2
Target Sequences: NM_004313 NP_004304.1 P32121

Publications (4)

1
Reduced expression of arrestin beta 2 by graft monocytes during acute rejection of rat kidneys. Zakrzewicz A, Krasteva G, Wilhelm J, Dietrich H, Wilker S, Padberg W, Wygrecka M, Grau V. Immunobiology. 2011 216:854-61. [PubMed:21193245] Related Antibodies: LS-C54486.
2
Acute ethanol exposure reduces serotonin receptor 1A internalization by increasing ubiquitination and degradation of ß-arrestin2. Deborah J Luessen, Haiguo Sun, Molly M McGinnis, Michael Hagstrom, Glen Marrs, Brian A McCool, Rong Chen. The Journal of biological chemistry. 2019 September;294:14068-14080. [Full Text Article] [PubMed:31366729] [PMC:PMC6755807] Related Antibodies: LS-B6008.
3
Pioglitazone Enhances ß-Arrestin2 Signaling and Ameliorates Insulin Resistance in Classical Insulin Target Tissues. Shaimaa El-Fayoumi, Rehab Mansour, Amr Mahmoud, Ahmed Fahmy, Islam Ibrahim. Pharmacology. 2021 June;106:409-417. [Full Text Article] [PubMed:34082428]
4
Dopamine D2 receptor dysfunction is rescued by adenosine A2A receptor antagonism in a model of DYT1 dystonia. Napolitano F, Pasqualetti M, Usiello A, Santini E, Pacini G, Sciamanna G, Errico F, Tassone A, Di Dato V, Martella G, Cuomo D, Fisone G, Bernardi G, Mandolesi G, Mercuri NB, Standaert DG, Pisani A. Neurobiology of disease. 2010 38:434-45. [PubMed:20227500] Related Antibodies: LS-C54486.
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Antibodies (35)
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ARRB2 / Beta Arrestin 2 (57)
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ARRB2 / Beta Arrestin 2 Antibody - Anti-Beta-Arrestin 2 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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ARRB2 / Beta Arrestin 2 Mouse anti-Human Monoclonal (3G1) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
ARRB2 / Beta Arrestin 2 Antibody - Anti-ARRB2 antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.
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ARRB2 / Beta Arrestin 2 Rabbit anti-Human Polyclonal (aa23-40) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µg/$460
ARRB2 / Beta Arrestin 2 Antibody - Goat Anti-Arrestin beta 2 Antibody (4µg/ml) staining of paraffin embedded Human Cerebellum. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining. This data is from a previous batch, not on sale.
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ARRB2 / Beta Arrestin 2 Goat anti-Human Polyclonal (aa351-361) Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µg/$503
ARRB2 / Beta Arrestin 2 Antibody - Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA002135LA01HU at dilution of 1:100
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ARRB2 / Beta Arrestin 2 Rabbit anti-Human Polyclonal Antibody
Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$294; 100 µg/$360
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ARRB2 / Beta Arrestin 2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$341
ARRB2 / Beta Arrestin 2 Antibody - Immunohistochemistry of paraffin-embedded human breast cancer tissue.
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ARRB2 / Beta Arrestin 2 Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
ARRB2 / Beta Arrestin 2 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
ARRB2 / Beta Arrestin 2 Protein - Recombinant Arrestin Beta 2 By SDS-PAGE
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E. coli
His-GST
45.9 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
ARRB2 / Beta Arrestin 2 Antibody - Detection of Human Beta-Arrestin 2 by Immunohistochemistry. Samples: FFPE sections of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-Beta-Arrestin 2 used at a dilution of 1:1000. Detection: DAB.
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ARRB2 / Beta Arrestin 2 Rabbit anti-Human Polyclonal (aa355-405) Antibody
Human
IHC, IHC-P, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
ARRB2 / Beta Arrestin 2 Antibody - ARRB2 / Beta Arrestin 2 antibody. IHC(P): Human Intestinal Cancer Tissue.
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ARRB2 / Beta Arrestin 2 Rabbit anti-Human Polyclonal (aa395-409) Antibody
Mouse, Rat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
ARRB2 / Beta Arrestin 2 Antibody - Antibody staining ARRB2 in human brain tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 3% BSA for 0. 5 hour at room temperature; antigen retrieval was by heat mediation with a citrate buffer (pH 6). Samples were incubated with primary antibody (1:25) for 1 hours at 37°C. A undiluted biotinylated goat polyvalent antibody was used as the secondary antibody.
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ARRB2 / Beta Arrestin 2 Rabbit anti-Human Polyclonal (aa264-298) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
200 µl/$393
ARRB2 / Beta Arrestin 2 Antibody
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ARRB2 / Beta Arrestin 2 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, WB
Unconjugated
50 µl/$286; 100 µl/$321
ARRB2 / Beta Arrestin 2 Antibody - 1:100 staining rat brain tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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ARRB2 / Beta Arrestin 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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ARRB2 / Beta Arrestin 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC
Unconjugated
20 µl/$275; 100 µl/$389
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ARRB2 / Beta Arrestin 2 Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
ARRB2 / Beta Arrestin 2 Antibody - Biotinylated antibody (1µg/ml) staining of Human Spleen lysate (35µg protein in RIPA buffer), exactly mirroring its parental non-biotinylated product. Primary incubation was 1 hour. Detected by chemiluminescence, using streptavidin-HRP and using NAP blocke
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ARRB2 / Beta Arrestin 2 Goat anti-Human Polyclonal (Internal Region) (Biotin) Antibody
Mouse, Rat, Human
IHC, IP, Peptide-ELISA, WB
Biotin Conjugated
100 µg/$503
ARRB2 / Beta Arrestin 2 Antibody - ARRB2 / Beta-Arrestin 2 antibody ARRB2(arrestin, beta 2) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human skin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ARRB2 / Beta Arrestin 2 Rabbit anti-Human Polyclonal (aa151-200) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$424
ARRB2 / Beta Arrestin 2 Antibody - ARRB2 / Beta-Arrestin 2 antibody ARRB2(arrestin, beta 2) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human skin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ARRB2 / Beta Arrestin 2 Rabbit anti-Human Polyclonal (aa151-200) (HRP) Antibody
Rabbit, Dog, Bovine, Pig, Horse, Bat, Gibbon, Orangutan, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
ARRB2 / Beta Arrestin 2 Antibody - ARRB2 / Beta-Arrestin 2 antibody ARRB2(arrestin, beta 2) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human skin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ARRB2 / Beta Arrestin 2 Rabbit anti-Human Polyclonal (aa151-200) (Biotin) Antibody
Rabbit, Dog, Bovine, Pig, Horse, Bat, Gibbon, Orangutan, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
ARRB2 / Beta Arrestin 2 Antibody - ARRB2 / Beta-Arrestin 2 antibody ARRB2(arrestin, beta 2) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human skin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ARRB2 / Beta Arrestin 2 Rabbit anti-Human Polyclonal (aa151-200) (FITC) Antibody
Rabbit, Dog, Bovine, Pig, Horse, Bat, Gibbon, Orangutan, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
ARRB2 / Beta Arrestin 2 Antibody - Immunofluorescence (IF) analysis of HeLa cells using Arrestin-beta-2 Monoclonal Antibody.
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ARRB2 / Beta Arrestin 2 Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Pig, Human
IF, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
ARRB2 / Beta Arrestin 2 Antibody - Detection of Human Beta-Arrestin 2 by Immunohistochemistry. Samples: FFPE sections of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-Beta-Arrestin 2 used at a dilution of 1:1000 (1 ug/ml) (left). Detection: DAB.
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ARRB2 / Beta Arrestin 2 Rabbit anti-Human Polyclonal (aa310-360) Antibody
Human
IHC, IHC-P, IP
Unconjugated
10 µg/$295; 100 µl/$514
ARRB2 / Beta Arrestin 2 Antibody - Western blot of ARRB2 pAb in extracts from Raw264.7 cells.
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ARRB2 / Beta Arrestin 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
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ARRB2 / Beta Arrestin 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$407
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ARRB2 / Beta Arrestin 2 Goat anti-Human Polyclonal Antibody
Human
IHC, IHC-P
Unconjugated
100 µg/$896
Viewing 1-25 of 57 product results



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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).