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ARSA / Arylsulfatase A
arylsulfatase A
ARSA / Arylsulfatase A hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Alternatively spliced transcript variants have been described for this gene.
| Gene Name: | arylsulfatase A |
| Synonyms: | ARSA, Arylsulfatase A, Cerebroside-sulfatase, MLD, ASA |
| Target Sequences: | NM_000487 NP_000478.3 P15289 |
Publications (3)
1
Acute kidney injury induced by protein-overload nephropathy down-regulates gene expression of hepatic cerebroside sulfotransferase in mice, resulting in reduction of liver and serum sulfatides. Zhang X, Nakajima T, Kamijo Y, Li G, Hu R, Kannagi R, Kyogashima M, Aoyama T, Hara A. Biochemical and biophysical research communications. 2009 390:1382-8.
[PubMed:19895791]
2
Hepatic Cerebroside Sulfotransferase Is Induced by PPAR Activation in Mice. Kimura T, Nakajima T, Kamijo Y, Tanaka N, Wang L, Hara A, Sugiyama E, Tanaka E, Gonzalez FJ, Aoyama T. PPAR research. 2012 2012:174932. (WB; Mouse)
[PubMed:22645601]
[PMC:PMC3356938]
3
Single Systemic Administration of a Gene Therapy Leading to Disease Treatment in Metachromatic Leukodystrophy Arsa Knock-Out Mice. Thia St Martin, Tania A Seabrook, Katherine Gall, Jenn Newman, Nancy Avila, April Hayes, Monicah Kivaa, Jason Lotterhand, Michael Mercaldi, Kruti Patel, Israel J Rivas, Stephen Woodcock, Teresa L Wright, Albert B Seymour, Omar L Francone, Jacinthe Gingras. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023 May;43:3567-3581. [Full Text Article]
[PubMed:36977578]
[PMC:PMC10184740]
Related Antibodies: LS-C688795.
☰ Filters
Products
Proteins
(22)
Type
Over-Expression Lysate
(10)
Recombinant
(12)
Target
ARSA / Arylsulfatase A
(22)
Application
SDS-PAGE
(1)
Publications
No
(22)
Tag
6His, C-terminus
(2)
GST
(1)
GST, N-terminus
(1)
His
(1)
His,C-terminus
(3)
His-T7
(1)
Myc-DDK (Flag)
(13)
Species
Human
(16)
Mouse
(1)
Source
293T Cells
(5)
E. coli
(2)
HEK 293 Cells
(11)
Human Cells
(1)
Mammalian Cells
(1)
Wheat Germ Extract
(2)
Purification
Purified
(4)
Low Endotoxin Level
Low endotoxin level
(5)
Biologically Active
Biologically active
(1)
HEK 293 Cells
His,C-terminus
SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human ARSA consists of 500 amino acids and predicts a molecular mass of 53 kDa. as estimated by SDS-PAGE under reducing conditions.
50 µg/$441; 500 µg/$1,697
HEK 293 Cells
Myc-DDK (Flag)
51.9 kDa
20 µg/$1,107
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
52.9kD
10 µg/$297; 50 µg/$468; 500 µg/$1,585; 1 mg/$2,157
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
HEK 293 Cells
Myc-DDK (Flag)
51.9 kDa
20 µg/$1,107
HEK 293 Cells
Myc-DDK (Flag)
51.9 kDa
20 µg/$1,107
293T Cells
Myc-DDK (Flag)
53.57 kDa
20 µg/$150
293T Cells
Myc-DDK (Flag)
53.81 kDa
20 µg/$215
293T Cells
Myc-DDK (Flag)
53.81 kDa
20 µg/$150
293T Cells
Myc-DDK (Flag)
53.57 kDa
20 µg/$215
293T Cells
Myc-DDK (Flag)
53.57 kDa
20 µg/$215
HEK 293 Cells
Myc-DDK (Flag)
53.81 kDa
100 µg/$494
HEK 293 Cells
Myc-DDK (Flag)
53.81 kDa
100 µg/$710
HEK 293 Cells
Myc-DDK (Flag)
53.57 kDa
100 µg/$710
HEK 293 Cells
Myc-DDK (Flag)
53.57 kDa
100 µg/$710
HEK 293 Cells
Myc-DDK (Flag)
53.57 kDa
100 µg/$494
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
52.9 kDa
10 µg/$384; 50 µg/$557
Wheat Germ Extract
GST
80 kDa
10 µg/$479; 25 µg/$670
E. coli
His-T7
33.1 kDa
10 µg/$276; 50 µg/$410; 100 µg/$655; 200 µg/$817; 1 mg/$1,899; 500 µg/$1,449; 5 mg/$2,857; 2 mg/$2,083
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
53 kDa
50 µg/$721; 500 µg/$4,249
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
53.5 kDa
50 µg/$721
Viewing 1-22
of 22
product results
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