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AS3MT
arsenic (+3 oxidation state) methyltransferase
Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO3H2, which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me2As(O)-OH.
| Gene Name: | arsenic (+3 oxidation state) methyltransferase |
| Synonyms: | AS3MT, Arsenite methyltransferase, CYT19, Methyltransferase cyt19, RP11-753C18.6 |
| Target Sequences: | NM_020682 NP_065733.2 Q9HBK9 |
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