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ASAP3 is a member of a subfamily of ADP-ribosylation factor(Arf) GTPase-activating proteins that contain additional ankyrin repeat and pleckstrin homology domains. The Arf GAP domain of this protein catalyzes the hydrolysis of GTP bound to Arf proteins. The encoded protein promotes cell differentiation and migration and has been implicated in cancer cell invasion. Alternative splicing results in multiple transcript variants.
Gene Name: | ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 |
Synonyms: | ASAP3, ACAP4, ARF6 GTPase-activating protein, CENTB6, DDEFL1, Centaurin, beta 6, UPLC1 |
Target Sequences: | NM_017707 NP_060177.2 Q8TDY4 |
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