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3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Enhances NF-kappa-B, SRF and AP1 transactivation.
Gene Name: | Activating Signal Cointegrator 1 Complex Subunit 3 |
Synonyms: | ASCC3, ASC1p200, ASC-1 complex subunit p200, DJ121G13.4, DJ467N11.1, p200, RNA helicase family, HELIC1, Helicase, ATP binding 1, RNAH, Trip4 complex subunit p200 |
Target Sequences: | NM_006828 NP_006819.2 Q8N3C0 |
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