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ASCL1 / MASH1

achaete-scute family bHLH transcription factor 1

ACSL1 is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. ACSL1 plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. The protein is highly expressed in medullary thyroid cancer and small cell lung cancer and may be a useful marker for these cancers. The presence of a CAG repeat in the gene suggests it may also play a role in tumor formation.

Gene Name: achaete-scute family bHLH transcription factor 1
Synonyms: ASCL1, Achaete-scute homolog 1, ASH-1, BHLHa46, Achaete scute protein, Achaete-scute complex-like 1, HASH1, MASH1, ASH1
Target Sequences: NM_004316 NP_004307.2 P50553

Publications (1)

1
Reciprocal expression of INSM1 and YAP1 defines subgroups in small cell lung cancer. McColl K, Wildey G, Sakre N, Lipka MB, Behtaj M, Kresak A, Chen Y, Yang M, Velcheti V, Fu P, Dowlati A. Oncotarget. 2017 August;8:73745-73756. (Human) [Full Text Article] [PubMed:29088741] [PMC:PMC5650296] Related Antibodies: LS-C177728.

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Antibodies (76)
Primary (76)
ASCL1 / MASH1 (76)
Human (68)
Mouse (26)
Rat (12)
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Chicken (3)
Dog (3)
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IHC (26)
IHC-P (10)
WB (65)
ELISA (37)
ICC (1)
IP (2)
Peptide-ELISA (4)
rabbit (72)
mouse (2)
goat (2)
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PathPlus Neuro (1)
Ig (1)
IgG (53)
IgG2a,k (1)
monoclonal mc (2)
polyclonal pc (73)
recombinant monoclonal rmc (1)
7E11 (1)
APC (1)
APC Conjugated (6)
Azide-free (4)
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Cy3 Conjugated (1)
Cy7 Conjugated (1)
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HRP Conjugated (11)
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Unconjugated (29)
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aa84-236 (8)
aa166-196 (7)
aa63-90 (7)
N-Terminus (6)
aa48-97 (4)
aa50-99 (4)
Asp220, C-Terminal (1)
Glu158 (1)
Internal (1)
aa109-158 (1)
aa137-237 (1)
aa36-50 (1)
aa79-91 (1)
No (75)
Yes (1)
ASCL1 / MASH1 Antibody - IHC of ASCL1 (E158) pAb in paraffin-embedded human brain tissue.
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ASCL1 / MASH1 Rabbit anti-Human Polyclonal (Glu158) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
ASCL1 / MASH1 Antibody - Anti-ASCL1 / MASH1 antibody IHC staining of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
ASCL1 / MASH1 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
ASCL1 / MASH1 Antibody - Western Blot analysis of ASCL1 expression in transfected 293T cell line by ASCL1 monoclonal antibody (M01), clone 7E11.Lane 1: ASCL1 transfected lysate(25.5 KDa).Lane 2: Non-transfected lysate.
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ASCL1 / MASH1 Mouse anti-Human Monoclonal (7E11) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
ASCL1 / MASH1 Antibody - ASCL1 / MASH1 antibody Western blot of 3 Cell lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ASCL1 / MASH1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
ASCL1 / MASH1 Antibody - ASCL1 / MASH1 antibody ARP32355_T100-NP_004307-ASCL1 (achaete-scute complex homolog 1 (Drosophila)) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ASCL1 / MASH1 Rabbit anti-Human Polyclonal (aa48-97) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$397
ASCL1 / MASH1 Antibody - Immunohistochemistry image of paraffin-embedded human brain tissue at a dilution of 1:100
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ASCL1 / MASH1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
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ASCL1 / MASH1 Mouse anti-Human Monoclonal (aa137-237) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$680
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ASCL1 / MASH1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
200 µl/$734
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ASCL1 / MASH1 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Mouse, Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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ASCL1 / MASH1 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Mouse, Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
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ASCL1 / MASH1 Rabbit anti-Human Polyclonal (N-Terminus) (APC) Antibody
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
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ASCL1 / MASH1 Rabbit anti-Human Polyclonal (N-Terminus) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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ASCL1 / MASH1 Rabbit anti-Human Polyclonal (N-Terminus) (PE) Antibody
Mouse, Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
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ASCL1 / MASH1 Rabbit Recombinant Monoclonal Antibody
ICC, IHC, IP, WB
Unconjugated
10 µl/$299; 100 µl/$548
ASCL1 / MASH1 Antibody - Immunohistochemistry analysis of ASCL1 antibody in paraffin-embedded human brain tissue.
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ASCL1 / MASH1 Rabbit anti-Human Polyclonal (aa109-158) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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ASCL1 / MASH1 Rabbit anti-Human Polyclonal (aa166-196) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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ASCL1 / MASH1 Rabbit anti-Human Polyclonal (aa166-196) (Biotin) Antibody
Mouse, Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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ASCL1 / MASH1 Rabbit anti-Human Polyclonal (aa166-196) (FITC) Antibody
Mouse, Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
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ASCL1 / MASH1 Rabbit anti-Human Polyclonal (aa166-196) (APC) Antibody
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
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ASCL1 / MASH1 Rabbit anti-Human Polyclonal (aa166-196) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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ASCL1 / MASH1 Rabbit anti-Human Polyclonal (aa166-196) (PE) Antibody
Mouse, Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
ASCL1 / MASH1 Antibody - Immunohistochemical analysis of paraffin-embedded human-lung, antibody was diluted at 1:200.
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ASCL1 / MASH1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ASCL1 / MASH1 Antibody - The anti-Hash1 antibody is used in Western blot to detect Hash1 in mouse lung tissue lysate.
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ASCL1 / MASH1 Rabbit anti-Human Polyclonal (aa166-196) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
ASCL1 / MASH1 Antibody - 1:100 staining human gastric tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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ASCL1 / MASH1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ASCL1 / MASH1 Antibody - Western blot analysis of anti-Ascl1 Antibody (C-term D220) in Hela cell line lysates (35ug/lane). Ascl1 (arrow) was detected using the purified Pab (1:160 dilution).
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ASCL1 / MASH1 Rabbit anti-Human Polyclonal (Asp220, C-Terminal) Antibody
Human
ELISA, WB
Unconjugated
400 µl/$393
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).