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ASCL2

achaete-scute family bHLH transcription factor 2

ASCL2 is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.

Gene Name: achaete-scute family bHLH transcription factor 2
Synonyms: ASCL2, Achaete-scute homolog 2, Achaete-scute complex-like 2, ASH-2, ASH2, BHLHa45, HASH2, MASH2
Target Sequences: NM_005170 NP_005161.1 Q99929

Publications (1)

1
Tumor-initiating stem cell shapes its microenvironment into an immunosuppressive barrier and pro-tumorigenic niche. Xi He, Sarah E Smith, Shiyuan Chen, Hua Li, Di Wu, Paloma I Meneses-Giles, Yongfu Wang, Mark Hembree, Kexi Yi, Xia Zhao, Fengli Guo, Jay R Unruh, Lucinda E Maddera, Zulin Yu, Allison Scott, Anoja Perera, Yan Wang, Chongbei Zhao, KyeongMin Bae, Andrew Box, Jeffrey S Haug, Fang Tao, Deqing Hu, Darrick M Hansen, Pengxu Qian, Subhrajit Saha, Dan Dixon, Shrikant Anant, Da Zhang, Edward H Lin, Weijing Sun, Leanne M Wiedemann, Linheng Li. Cell reports. 2021 Sep;36:109674. [Full Text Article] [PubMed:34496236] [PMC:PMC8451448] Related Antibodies: LS-C126891.

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Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
ASCL2 (5)
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10His, N-terminus + Myc, C-terminus (1)
GST (1)
Myc-DDK (Flag) (3)
Human (3)
Mouse (1)
293T Cells (1)
E. coli (1)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (2)
ASCL2 Protein - Purified recombinant protein ASCL2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
20 kDa
20 µg/$1,107
ASCL2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
20 kDa
20 µg/$150
ASCL2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
20 kDa
100 µg/$494
ASCL2 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
10His, N-terminus + Myc, C-terminus
32.8 kDa
20 µg/$405; 1 mg/$1,679; 100 µg/$598
ASCL2 Protein - 12.5% SDS-PAGE of human ASCL2 stained with Coomassie Blue
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Wheat Germ Extract
GST
46.6 kDa
2 µg/$439
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).