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Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis.
Gene Name: | ash2 (absent, small, or homeotic)-like (Drosophila) |
Synonyms: | ASH2L, ASH2, ASH2-like protein, ASH2L1, ASH2L2, Bre2 |
Target Sequences: | NM_004674 NP_004665.2 Q9UBL3 |
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