ASIC1 / ACCN2

acid-sensing (proton-gated) ion channel 1

Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca2+ entry into neurons upon acidosis. This Ca2+ overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca2+ concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

ASIC1 / ACCN2 (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human ASIC1 / ACCN2 Protein (Recombinant GST, N-terminus) (aa96-185) - LS-G64629

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

25 µg/$670; 10 µg/$479

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Human ASIC1 / ACCN2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81815

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.7 kDa

Price:

20 µg/$215

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Human ASIC1 / ACCN2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68277

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.7 kDa

Price:

20 µg/$1,107

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ASIC1 / ACCN2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118773

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.7 kDa

Price:

100 µg/$710

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Human ASIC1 / ACCN2 Protein (Recombinant GST) (Full Length) - LS-G27330

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

86.3 kDa

Price:

10 µg/$479; 25 µg/$670

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