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Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding.
Gene Name: | Astacin-like metallo-endopeptidase (M12 family) |
Synonyms: | ASTL |
Target Sequences: | NP_001002036.3 |
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