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ASZ1 / Orf3

ankyrin repeat, SAM and basic leucine zipper domain containing 1

Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

Gene Name: ankyrin repeat, SAM and basic leucine zipper domain containing 1
Synonyms: ASZ1, Ankyrin-like 1, ANKL1, C7orf7, CT1.19, GASZ, Orf3, Alp1, Ankyrin-like protein 1
Target Sequences: NP_570124.1 Q8WWH4

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Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
ASZ1 / Orf3 (5)
No (5)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (3)
Human (4)
293T Cells (1)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (1)
ASZ1 / Orf3 Protein - 12.5% SDS-PAGE of human ASZ1 stained with Coomassie Blue
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Wheat Germ Extract
GST
70.4 kDa
10 µg/$479; 25 µg/$670
ASZ1 / Orf3 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
ASZ1 / Orf3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
53.3 kDa
20 µg/$215
ASZ1 / Orf3 Protein - Purified recombinant protein ASZ1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
53.3 kDa
20 µg/$1,107
ASZ1 / Orf3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
53.3 kDa
100 µg/$710
Viewing 1-5 of 5 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).