ATF2

activating transcription factor 2

Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.

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Products

ELISA Kits (18)

Type

Cell-Based (1)

Cell-Based Phosphorylation (6)

Custom (3)

DNA Binding (1)

DNA Binding Phosphorylation (3)

Sandwich (4)

Target

ATF2 (18)

Reactivity

Human (14)

Mouse (11)

Rat (13)

Chicken (1)

Format

12 x 8-Well Microstrips (4)

96-Well Microplate (8)

96-Well Strip Plate (6)

Publications

No (18)

Sample Type

Adherent Cell Cultures (7)

Cell Lysates (4)

Nuclear Lysates (4)

Plasma (4)

Serum (4)

Tissue Homogenates (2)

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Chicken ATF2 (Custom ELISA) ELISA Kit - LS-F20206

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Chicken

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$929

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Mouse ATF2 (Custom ELISA) ELISA Kit - LS-F20207

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Human ATF2 (Custom ELISA) ELISA Kit - LS-F20208

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Human ATF2 (Sandwich ELISA) ELISA Kit - LS-F22943

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

15.625 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Human ATF2 (Sandwich ELISA) ELISA Kit - LS-F36769

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

15.625 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Rat ATF2 (Sandwich ELISA) ELISA Kit - LS-F33992

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Rat ATF2 (Sandwich ELISA) ELISA Kit - LS-F10893

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Mouse/Human/Rat Phospho-ATF2 (Ser112) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1452

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Mouse/Human/Rat Phospho-ATF2 (Ser62) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1453

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Mouse/Human/Rat Phospho-ATF2 (Thr691) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1454

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

Select

Mouse/Human/Rat Phospho-ATF2 (Thr71) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1455

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

Select

Mouse/Human/Rat Phospho-ATF2 (Thr73) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1456

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

Select

Mouse/Human/Rat ATF2 (Cell-Based ELISA) ELISA Kit - LS-F1808

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

Select

Mouse/Human/Rat Phospho-ATF2 (Thr71) (DNA-Binding Phosphorylation ELISA) ELISA Kit - LS-F859

Type:

DNA Binding Phosphorylation

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Nuclear Lysates

Price:

1 Plate/$735

Select

Mouse/Human/Rat Phospho-ATF2 (Ser480) (DNA-Binding Phosphorylation ELISA) ELISA Kit - LS-F857

Type:

DNA Binding Phosphorylation

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Nuclear Lysates

Price:

1 Plate/$735

Select

Mouse/Human/Rat Phospho-ATF2 (Thr69) (DNA-Binding Phosphorylation ELISA) ELISA Kit - LS-F858

Type:

DNA Binding Phosphorylation

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Nuclear Lysates

Price:

1 Plate/$735

Select

Human/Rat Phospho-ATF2 (Ser480) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1315

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

Select

Mouse/Human/Rat ATF2 (DNA-Binding ELISA) ELISA Kit - LS-F739

Type:

DNA Binding

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Nuclear Lysates

Price:

1 Plate/$662

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