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ATF4
activating transcription factor 4
Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes.
| Gene Name: | activating transcription factor 4 |
| Family/Subfamily: | Transcription factor , not assigned-Transcription factor |
| Synonyms: | ATF4, CREB-2, CREB2, TXREB, DNA-binding protein TAXREB67, TAXREB67 |
| Target Sequences: | NM_001675 NP_001666.2 P18848 |
Publications (2)
1
The Transcription Factor ATF4 Promotes Expression of Cell Stress Genes and Cardiomyocyte Death in a Cellular Model of Atrial Fibrillation. Freundt JK, Frommeyer G, Wötzel F, Huge A, Hoffmeier A, Martens S, Eckardt L, Lange PS. BioMed research international. 2018 May;2018:3694362. (Mouse)
[Full Text Article]
[PubMed:30003094]
[PMC:PMC5996409]
Related Antibodies: LS-B3517.
2
A thrombospondin-dependent pathway for a protective ER stress response. Lynch JM, Maillet M, Vanhoutte D, Schloemer A, Sargent MA, Blair NS, Lynch KA, Okada T, Aronow BJ, Osinska H, Prywes R, Lorenz JN, Mori K, Lawler J, Robbins J, Molkentin JD. Cell. 2012 Jun;149:1257-68. [Full Text Article]
[PubMed:22682248]
[PMC:PMC3372931]
Related Antibodies: LS-B3517.
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ATF4 Rabbit anti-Mouse Polyclonal (N-Terminus) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
ATF4 Rabbit anti-Mouse Polyclonal (N-Terminus) Antibody
Mouse
IHC, IHC-P, WB
Unconjugated
100 µl/$485
ATF4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
ATF4 Rabbit anti-Human Polyclonal (pSer245) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$315
ATF4 Mouse anti-Human Monoclonal (2B3) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
ATF4 Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse
WB
Unconjugated
100 µl/$424
ATF4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
ATF4 Rabbit anti-Zebrafish Polyclonal (aa288-314) Antibody
Zebrafish
WB
Unconjugated
400 µl/$393
ATF4 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$299
ATF4 Rabbit anti-Human Polyclonal (aa171-198) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
ATF4 Goat anti-Human Polyclonal (aa339-351) Antibody
Mouse, Rat, Hamster, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$503
ATF4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ATF4 Mouse anti-Human Monoclonal (aa171-271) Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$705
ATF4 Rabbit anti-Human Polyclonal (aa212-261) Antibody
Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
ATF4 Rabbit anti-Human Polyclonal (p245) Antibody
Human
ELISA, IHC
Unconjugated
100 µg/$357
ATF4 Rabbit anti-Human Polyclonal (160-240 aa) Antibody
Mouse, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ATF4 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µl/$450
ATF4 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$351
ATF4 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
Compet, ELISA, ICC, IHC, IP, WB
Unconjugated
100 µl/$397
ATF4 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Dog, Human, Monkey, Chimpanzee, Gibbon
Compet, ELISA, ICC, IHC, IP, WB
HRP Conjugated
100 µl/$442
ATF4 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Dog, Human, Monkey, Chimpanzee, Gibbon
Compet, ELISA, ICC, IHC, IP, WB
Biotin Conjugated
100 µl/$442
ATF4 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Dog, Human, Monkey, Chimpanzee, Gibbon
Compet, ELISA, ICC, IHC, IP, WB
FITC Conjugated
100 µl/$442
ATF4 Mouse anti-Human Monoclonal (2A6F12) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µl/$459
ATF4 Mouse anti-Human Monoclonal (aa25-327) (S360A-24) Antibody
Rat, Human
ICC, IHC, WB
Unconjugated
100 µg/$442
ATF4 Mouse anti-Human Monoclonal (aa25-327) (Atto 594) (S360A-24) Antibody
Rat, Human
ICC, IHC, WB
Atto 594 Conjugated
100 µg/$479
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