ATF4

activating transcription factor 4

Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes.

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Products

Proteins (8)

Type

Recombinant (8)

Target

ATF4 (8)

Publications

No (8)

Tag

GST (2)

GST, N-terminus (1)

His, N-Terminal (1)

His-Calmodulin (1)

His-T7 (3)

Species

Human (6)

Mouse (1)

Rat (1)

Source

E. coli (5)

Wheat Germ Extract (3)

Purification

Purified (3)

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Rat ATF4 Protein (Recombinant His-T7) (aa125-329) - LS-G13753

Source:

E. coli

Tag:

His-T7

Molecular Weight:

26.2 kDa

Price:

10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231

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Mouse ATF4 Protein (Recombinant His-T7) (aa126-291) - LS-G13741

Source:

E. coli

Tag:

His-T7

Molecular Weight:

21.6 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Human ATF4 Protein (Recombinant His-T7) (aa130-347) - LS-G13735

Source:

E. coli

Tag:

His-T7

Molecular Weight:

27.8 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human ATF4 Protein (Recombinant GST, N-terminus) (aa171-270) - LS-G57839

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ATF4 Protein (Recombinant His, N-Terminal) - LS-G144136

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

38.4 kDa

Price:

50 µg/$419

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Human ATF4 Protein (Recombinant GST) (Full Length) - LS-G27554

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

64.35 kDa

Price:

2 µg/$439

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Human ATF4 Protein (Recombinant GST) (Full Length) - LS-G27555

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

64.35 kDa

Price:

2 µg/$439

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Human ATF4 Protein (Recombinant His-Calmodulin) - LS-G1361

Source:

E. coli

Tag:

His-Calmodulin

Price:

50 µg/$411; 250 µg/$985; 10 µg/$276

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