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ATF6

activating transcription factor 6

ATF6 is a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.

Gene Name: activating transcription factor 6
Synonyms: ATF6, ATF6-alpha, ATF6A
Target Sequences: NM_007348 NP_031374.2 P18850

Publications (2)

1
The activation of retinal HCA2 receptors by systemic beta-hydroxybutyrate inhibits diabetic retinal damage through reduction of endoplasmic reticulum stress and the NLRP3 inflammasome. Trotta MC, Maisto R, Guida F, Boccella S, Luongo L, Balta C, D'Amico G, Herman H, Hermenean A, Bucolo C, D'Amico M. PloS one. 2019 January;14:e0211005. [Full Text Article] [PubMed:30657794] [PMC:PMC6338370]
2
Binge ethanol exposure causes endoplasmic reticulum stress, oxidative stress and tissue injury in the pancreas. Zhenhua Ren, Xin Wang, Mei Xu, Fanmuyi Yang, Jacqueline A Frank, Zun-Ji Ke, Jia Luo. Oncotarget. 2016 August;7:54303-54316. [Full Text Article] [PubMed:27527870] [PMC:PMC5342343]

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ELISA Kits (12)
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ATF6 (12)
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Porcine (1)
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12 x 8-Well Microstrips (2)
96-Well Microplate (1)
96-Well Strip Plate (9)
No (10)
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Cell Lysates (1)
Plasma (5)
Serum (5)
Tissue Homogenates (3)
ATF6 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
ATF6 ELISA Kit
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Sandwich
96-Well Microplate
Human
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
ATF6 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$715
ATF6 ELISA Kit
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Sandwich
12 x 8-Well Microstrips
Rat
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
ATF6 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
ATF6 ELISA Kit
Select
Sandwich
12 x 8-Well Microstrips
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
ATF6 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Chicken
6.25 - 400 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
ATF6 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Guinea pig
1.25 - 80 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
ATF6 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
ATF6 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Porcine
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
ATF6 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Sheep
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$691
ATF6 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
6.25 - 400 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).