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Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane.
Gene Name: | autophagy related 16-like 1 (S. cerevisiae) |
Synonyms: | ATG16L1, APG16-like 1, APG16L, APG16L beta, ATG16L, Autophagy-related protein 16-1, IBD10, WD repeat domain 30, ATG16A, WDR30 |
Target Sequences: | NM_017974 NP_060444.3 Q676U5 |
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