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ATG16L1 / ATG16L

autophagy related 16-like 1 (S. cerevisiae)

Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane.

Gene Name:	autophagy related 16-like 1 (S. cerevisiae)
Synonyms:	ATG16L1, APG16-like 1, APG16L, APG16L beta, ATG16L, Autophagy-related protein 16-1, IBD10, WD repeat domain 30, ATG16A, WDR30
Target Sequences:	NM_017974 NP_060444.3 Q676U5

Publications (7)

Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2. Plantinga TS, Crisan TO, Oosting M, van de Veerdonk FL, de Jong DJ, Philpott DJ, van der Meer JW, Girardin SE, Joosten LA, Netea MG. Gut. 2011 60:1229-35. [PubMed:21406388]

Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease. Nascimento-Ferreira I, Santos-Ferreira T, Sousa-Ferreira L, Auregan G, Onofre I, Alves S, Dufour N, Colomer Gould VF, Koeppen A, Dglon N, Pereira de Almeida L. Brain : a journal of neurology. 2011 134:1400-15. [PubMed:21478185] Related Antibodies: LS-C156571.

NOD2 enhances the innate response of alveolar macrophages to Mycobacterium tuberculosis in humans. Jurez E, Carranza C, Hernndez-Snchez F, Len-Contreras JC, Hernndez-Pando R, Escobedo D, Torres M, Sada E. European journal of immunology. 2012 42:880-9. (Human) [PubMed:22531915]

Amino acid starvation induced by invasive bacterial pathogens triggers an innate host defense program. Tattoli I, Sorbara MT, Vuckovic D, Ling A, Soares F, Carneiro LA, Yang C, Emili A, Philpott DJ, Girardin SE. Cell host & microbe. 2012 11:563-75. (WB; Human) [PubMed:22704617]

Identification of autophagic vacuoles and regulators of autophagy in villous trophoblast from normal term pregnancies and in fetal growth restriction. Curtis S, Jones CJ, Garrod A, Hulme CH, Heazell AE. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 2013 26:339-46. (IHC; Human) [PubMed:23039021]

Downregulation of Autophagy-Related Proteins 1, 5, and 16 in Testicular Germ Cell Tumors Parallels Lowered LC3B and Elevated p62 Levels, Suggesting Reduced Basal Autophagy. Liu H, He Z, Bode P, Moch H, Simon HU. Frontiers in oncology. 2018 September;8:366. [Full Text Article] [PubMed:30245976] [PMC:PMC6137693] Related Antibodies: LS-B2723.

Machine learning with autophagy-related proteins for discriminating renal cell carcinoma subtypes. Zhaoyue He, He Liu, Holger Moch, Hans-Uwe Simon. Scientific reports. 2020 Jan;10:720. [Full Text Article] [PubMed:31959887] [PMC:PMC6971298] Related Antibodies: LS-B2723.

Human ATG16L1 / ATG16L (Sandwich ELISA) ELISA Kit - LS-F7516

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$792

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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