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ATG16L1 / ATG16L
autophagy related 16-like 1 (S. cerevisiae)
Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane.
| Gene Name: | autophagy related 16-like 1 (S. cerevisiae) |
| Synonyms: | ATG16L1, APG16-like 1, APG16L, APG16L beta, ATG16L, Autophagy-related protein 16-1, IBD10, WD repeat domain 30, ATG16A, WDR30 |
| Target Sequences: | NM_017974 NP_060444.3 Q676U5 |
Publications (7)
1
Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2. Plantinga TS, Crisan TO, Oosting M, van de Veerdonk FL, de Jong DJ, Philpott DJ, van der Meer JW, Girardin SE, Joosten LA, Netea MG. Gut. 2011 60:1229-35.
[PubMed:21406388]
2
Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease. Nascimento-Ferreira I, Santos-Ferreira T, Sousa-Ferreira L, Auregan G, Onofre I, Alves S, Dufour N, Colomer Gould VF, Koeppen A, Dglon N, Pereira de Almeida L. Brain : a journal of neurology. 2011 134:1400-15.
[PubMed:21478185]
Related Antibodies: LS-C156571.
3
NOD2 enhances the innate response of alveolar macrophages to Mycobacterium tuberculosis in humans. Jurez E, Carranza C, Hernndez-Snchez F, Len-Contreras JC, Hernndez-Pando R, Escobedo D, Torres M, Sada E. European journal of immunology. 2012 42:880-9. (Human)
[PubMed:22531915]
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Products
Proteins
(10)
Type
Over-Expression Lysate
(4)
Recombinant
(6)
Target
ATG16L1 / ATG16L
(10)
Publications
No
(10)
Tag
GST
(1)
GST, N-terminus
(1)
His
(1)
His-GST-S
(1)
His-SUMO
(1)
His-T7
(1)
Myc-DDK (Flag)
(4)
Species
Human
(8)
Source
293T Cells
(2)
E. coli
(3)
HEK 293 Cells
(2)
Wheat Germ Extract
(2)
Yeast
(1)
Purification
Purified
(1)
Wheat Germ Extract
GST
84.7 kDa
2 µg/$439
293T Cells
Myc-DDK (Flag)
68.1 kDa
20 µg/$215
293T Cells
Myc-DDK (Flag)
58.7 kDa
20 µg/$150
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
HEK 293 Cells
Myc-DDK (Flag)
68.1 kDa
100 µg/$710
HEK 293 Cells
Myc-DDK (Flag)
58.7 kDa
100 µg/$494
E. coli
His-SUMO
84.22 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Yeast
His
70.27 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
E. coli
His-T7
33.1 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
E. coli
His-GST-S
62.8 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
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