ATG18 / WIPI1

WD repeat domain, phosphoinositide interacting 1

Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation-induced autophagy. May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

ATG18 / WIPI1 (4)

Publications

No (4)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human ATG18 / WIPI1 Protein (Recombinant GST) (Full Length) - LS-G34165

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

75.1 kDa

Price:

10 µg/$479; 25 µg/$670

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Human ATG18 / WIPI1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G93833

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.5 kDa

Price:

20 µg/$150

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ATG18 / WIPI1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101519

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.5 kDa

Price:

100 µg/$494

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Human ATG18 / WIPI1 Protein (Recombinant GST, N-terminus) (aa348-445) - LS-G62649

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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