ATP1A1

ATP1A1 belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene.

Publications (39)

Subcellular distribution of sodium pump isoform subunits in mammalian cardiac myocytes. McDonough AA, Zhang Y, Shin V, Frank JS. The American journal of physiology. 1996 270:C1221-7. [PubMed:8928749]

Reversible effects of acute hypertension on proximal tubule sodium transporters. Zhang Y, Magyar CE, Norian JM, Holstein-Rathlou NH, Mircheff AK, McDonough AA. The American journal of physiology. 1998 274:C1090-100. [PubMed:9575807]

In vivo PTH provokes apical NHE3 and NaPi2 redistribution and Na-K-ATPase inhibition. Zhang Y, Norian JM, Magyar CE, Holstein-Rathlou NH, Mircheff AK, McDonough AA. The American journal of physiology. 1999 276:F711-9. [PubMed:10330053]

Proximal tubule Na transporter responses are the same during acute and chronic hypertension. Magyar CE, Zhang Y, Holstein-Rathlou NH, McDonough AA. American journal of physiology. Renal physiology. 2000 279:F358-69. [PubMed:10919857]

18O-exchange evidence that mutations of arginine in a signature sequence for P-type pumps affect inorganic phosphate binding. Farley RA, Elquza E, Mller-Ehmsen J, Kane DJ, Nagy AK, Kasho VN, Faller LD. Biochemistry. 2001 40:6361-70. [PubMed:11371198]

All human Na(+)-K(+)-ATPase alpha-subunit isoforms have a similar affinity for cardiac glycosides. Wang J, Velotta JB, McDonough AA, Farley RA. American journal of physiology. Cell physiology. 2001 281:C1336-43. (WB; Human) [PubMed:11546672]

Chronic renal injury-induced hypertension alters renal NHE3 distribution and abundance. Yang LE, Zhong H, Leong PK, Perianayagam A, Campese VM, McDonough AA. American journal of physiology. Renal physiology. 2003 284:F1056-65. [PubMed:12554635]

Amelioration of radiation-induced fibrosis: inhibition of transforming growth factor-beta signaling by halofuginone. Xavier S, Piek E, Fujii M, Javelaud D, Mauviel A, Flanders KC, Samuni AM, Felici A, Reiss M, Yarkoni S, Sowers A, Mitchell JB, Roberts AB, Russo A. The Journal of biological chemistry. 2004 279:15167-76. [PubMed:14732719]

Novel role of phospholipase C-delta1: regulation of liver mitochondrial Ca2+ uptake. Knox CD, Belous AE, Pierce JM, Wakata A, Nicoud IB, Anderson CD, Pinson CW, Chari RS. American journal of physiology. Gastrointestinal and liver physiology. 2004 287:G533-40. (WB; Rat) [PubMed:15107298]

FAT/CD36-mediated long-chain fatty acid uptake in adipocytes requires plasma membrane rafts. Pohl J, Ring A, Korkmaz U, Ehehalt R, Stremmel W. Molecular biology of the cell. 2005 16:24-31. [PubMed:15496455] [PMC:PMC539148]

Monocrotaline pyrrole-induced endothelial cell megalocytosis involves a Golgi blockade mechanism. Shah M, Patel K, Sehgal PB. American journal of physiology. Cell physiology. 2005 288:C850-62. [PubMed:15561761]

A biomimetic tissue from cultured normal human urothelial cells: analysis of physiological function. Cross WR, Eardley I, Leese HJ, Southgate J. American journal of physiology. Renal physiology. 2005 289:F459-68. [PubMed:15784840]

Effects of ACE inhibition on proximal tubule sodium transport. Leong PK, Devillez A, Sandberg MB, Yang LE, Yip DK, Klein JB, McDonough AA. American journal of physiology. Renal physiology. 2006 290:F854-63. [PubMed:16263808]

The C-terminal flavin domain of gp91phox bound to plasma membranes of granulocyte-like X-CGD PLB-985 cells is sufficient to anchor cytosolic oxidase components and support NADPH oxidase-associated diaphorase activity independent of cytosolic phospholipase. Pessach I, Shmelzer Z, Leto TL, Dinauer MC, Levy R. Journal of leukocyte biology. 2006 80:630-9. [PubMed:16844764]

A three-dimensional model of human organic anion transporter 1: aromatic amino acids required for substrate transport. Perry JL, Dembla-Rajpal N, Hall LA, Pritchard JB. The Journal of biological chemistry. 2006 281:38071-9. [PubMed:17038320] [PMC:PMC1847411]

The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of beta-amyloid precursor protein. Tansley GH, Burgess BL, Bryan MT, Su Y, Hirsch-Reinshagen V, Pearce J, Chan JY, Wilkinson A, Evans J, Naus KE, McIsaac S, Bromley K, Song W, Yang HC, Wang N, DeMattos RB, Wellington CL. Journal of lipid research. 2007 48:1022-34. [PubMed:17293612]

Effects of apoA-V on HDL and VLDL metabolism in APOC3 transgenic mice. Qu S, Perdomo G, Su D, D'Souza FM, Shachter NS, Dong HH. Journal of lipid research. 2007 48:1476-87. [PubMed:17438339] [PMC:PMC2665252]

Lipid rafts are required for Kit survival and proliferation signals. Jahn T, Leifheit E, Gooch S, Sindhu S, Weinberg K. Blood. 2007 110:1739-47. [PubMed:17554062] [PMC:PMC1976347]

Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins. Padilla BE, Cottrell GS, Roosterman D, Pikios S, Muller L, Steinhoff M, Bunnett NW. The Journal of cell biology. 2007 179:981-97. [PubMed:18039931] [PMC:PMC2099187]

Evolutionarily conserved gene family important for fat storage. Kadereit B, Kumar P, Wang WJ, Miranda D, Snapp EL, Severina N, Torregroza I, Evans T, Silver DL. Proceedings of the National Academy of Sciences of the United States of America. 2008 105:94-9. [PubMed:18160536] [PMC:PMC2224239]

Distinct endocytic recycling of myelin proteins promotes oligodendroglial membrane remodeling. Winterstein C, Trotter J, Krmer-Albers EM. Journal of cell science. 2008 121:834-42. [PubMed:18303048]

ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo. Burgess BL, Parkinson PF, Racke MM, Hirsch-Reinshagen V, Fan J, Wong C, Stukas S, Theroux L, Chan JY, Donkin J, Wilkinson A, Balik D, Christie B, Poirier J, Ltjohann D, Demattos RB, Wellington CL. Journal of lipid research. 2008 49:1254-67. [PubMed:18314463]

Comparison of expressed human and mouse sodium/iodide symporters reveals differences in transport properties and subcellular localization. Dayem M, Basquin C, Navarro V, Carrier P, Marsault R, Chang P, Huc S, Darrouzet E, Lindenthal S, Pourcher T. The Journal of endocrinology. 2008 197:95-109. [PubMed:18372236]

Immunoanalysis indicates that the sodium iodide symporter is not overexpressed in intracellular compartments in thyroid and breast cancers. Peyrottes I, Navarro V, Ondo-Mendez A, Marcellin D, Bellanger L, Marsault R, Lindenthal S, Ettore F, Darcourt J, Pourcher T. European journal of endocrinology / European Federation of Endocrine Societies. 2009 160:215-25. [PubMed:19029227]

Development and validation of a novel protein extraction methodology for quantitation of protein expression in formalin-fixed paraffin-embedded tissues using western blotting. Nirmalan NJ, Harnden P, Selby PJ, Banks RE. The Journal of pathology. 2009 217:497-506. [PubMed:19156775]

Comprehensive analysis of expression, subcellular localization, and cognate pairing of SNARE proteins in oligodendrocytes. Feldmann A, Winterstein C, White R, Trotter J, Krmer-Albers EM. Journal of neuroscience research. 2009 87:1760-72. [PubMed:19185015]

A mouse model for degeneration of the spiral ligament. Kada S, Nakagawa T, Ito J. Journal of the Association for Research in Otolaryngology : JARO. 2009 10:161-72. (IHC) [PubMed:19212789] [PMC:PMC2674195]

Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling. Cottrell GS, Padilla BE, Amadesi S, Poole DP, Murphy JE, Hardt M, Roosterman D, Steinhoff M, Bunnett NW. The Journal of biological chemistry. 2009 284:22411-25. [PubMed:19531493] [PMC:PMC2755963]

Cell surface relocalization of the endoplasmic reticulum chaperone and unfolded protein response regulator GRP78/BiP. Zhang Y, Liu R, Ni M, Gill P, Lee AS. The Journal of biological chemistry. 2010 285:15065-75. [PubMed:20208072] [PMC:PMC2865300]

Altered ion transport by thyroid epithelia from CFTR(-/-) pigs suggests mechanisms for hypothyroidism in cystic fibrosis. Li H, Ganta S, Fong P. Experimental physiology. 2010 95:1132-44. [PubMed:20729267] [PMC:PMC2991370]

Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?. Krmer-Albers EM, Bretz N, Tenzer S, Winterstein C, Mbius W, Berger H, Nave KA, Schild H, Trotter J. Proteomics. Clinical applications. 2007 1:1446-61. [PubMed:21136642]

Critical role for CD38-mediated Ca2+ signaling in thrombin-induced procoagulant activity of mouse platelets and hemostasis. Mushtaq M, Nam TS, Kim UH. The Journal of biological chemistry. 2011 286:12952-8. [PubMed:21339289] [PMC:PMC3075642]

A novel strategy for the comprehensive analysis of the biomolecular composition of isolated plasma membranes. Thimiri Govinda Raj DB, Ghesquire B, Tharkeshwar AK, Coen K, Derua R, Vanderschaeghe D, Rysman E, Bagadi M, Baatsen P, De Strooper B, Waelkens E, Borghs G, Callewaert N, Swinnen J, Gevaert K, Annaert W. Molecular systems biology. 2011 7:541. [PubMed:22027552] [PMC:PMC3261717]

A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death. Garg AD, Krysko DV, Verfaillie T, Kaczmarek A, Ferreira GB, Marysael T, Rubio N, Firczuk M, Mathieu C, Roebroek AJ, Annaert W, Golab J, de Witte P, Vandenabeele P, Agostinis P. The EMBO journal. 2012 31:1062-79. [PubMed:22252128] [PMC:PMC3298003]

Regulation of glucose transport by ROCK1 differs from that of ROCK2 and is controlled by actin polymerization. Chun KH, Araki K, Jee Y, Lee DH, Oh BC, Huang H, Park KS, Lee SW, Zabolotny JM, Kim YB. Endocrinology. 2012 153:1649-62. (WB; Mouse) [PubMed:22355071] [PMC:PMC3320261]

Functional loss of the reduced folate carrier enhances the antitumor activities of novel antifolates with selective uptake by the proton-coupled folate transporter. Desmoulin SK, Wang L, Polin L, White K, Kushner J, Stout M, Hou Z, Cherian C, Gangjee A, Matherly LH. Molecular pharmacology. 2012 82:591-600. [PubMed:22740639] [PMC:PMC3463226]

Extracellular matrix lumican promotes bacterial phagocytosis, and Lum-/- mice show increased Pseudomonas aeruginosa lung infection severity. Shao H, Lee S, Gae-Scott S, Nakata C, Chen S, Hamad AR, Chakravarti S. The Journal of biological chemistry. 2012 287:35860-72. (ICC; Mouse) [PubMed:22865855] [PMC:PMC3476255]

Anti-apoptotic role of caspase-cleaved GAB1 adaptor protein in hepatocyte growth factor/scatter factor-MET receptor protein signaling. Le Goff A, Ji Z, Leclercq B, Bourette RP, Mougel A, Guerardel C, de Launoit Y, Vicogne J, Goormachtigh G, Fafeur V. The Journal of biological chemistry. 2012 287:35382-96. (WB; Dog) [PubMed:22915589] [PMC:PMC3471683]

LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis. Matta S, Van Kolen K, da Cunha R, van den Bogaart G, Mandemakers W, Miskiewicz K, De Bock PJ, Morais VA, Vilain S, Haddad D, Delbroek L, Swerts J, Chvez-Gutirrez L, Esposito G, Daneels G, Karran E, Holt M, Gevaert K, Moechars DW, De Strooper B, Verstreken. Neuron. 2012 75:1008-21. (WB; Drosophila) [PubMed:22998870]

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Gene Name:	ATPase, Na+/K+ transporting, alpha 1 polypeptide
Family/Subfamily:	Transporter , ATPase - P type, type IIC
Synonyms:	ATP1A1, Na+, K+ ATPase alpha subunit, Na,K-ATPase alpha-1 subunit, Na+/K+ ATPase 1, Sodium pump 1, Sodium pump subunit alpha-1
Target Sequences:	NM_000701 NP_000692.2 P05023

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ATPase, Na+/K+ transporting, alpha 1 polypeptide

Publications (39)

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