ATP2A2 / SERCA2

ATPase, Ca++ transporting, cardiac muscle, slow twitch 2

ATP2a2 (Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 ATPase), also known as SERCA2 (Sarcoplasmic reticulum Ca(2+)-ATPase 2), belongs to the large family of P-type cation pumps that couple ATP hydrolysis with cation transport across membranes. The ATP2a2 pump maintains low cytosolic Ca(2+) concentrations by actively transporting Ca(2+) from the cytosol into the sarco/endoplasmic reticulum lumen. Experiments on ATP2a2-null mice demonstrate that this enzyme may be important for the cardiac function. Germ-line mutations in ATP2a2 are the cause of the Darier-White disease (keratosis follicularis), which is characterized by warty papules and plaques in seborrheic areas (central trunk, flexures, scalp, and forehead), palmoplantar pits, and distinctive nail abnormalities.

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Proteins (3)

Type

Recombinant (3)

Target

ATP2A2 / SERCA2 (3)

Publications

No (3)

Tag

6His, N-terminus (1)

GST (1)

His-GST (1)

Species

Human (3)

Source

E. coli (2)

Wheat Germ Extract (1)

Purification

Purified (2)

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Human ATP2A2 / SERCA2 Protein (Recombinant GST) (Full Length) - LS-G27566

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

136.1 kDa

Price:

10 µg/$479; 25 µg/$670

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Human ATP2A2 / SERCA2 Protein (Recombinant 6His, N-terminus) (aa314-756) - LS-G57510

Source:

E. coli

Tag:

6His, N-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human ATP2A2 / SERCA2 Protein (Recombinant His-GST) (aa315-756) - LS-G25723

Source:

E. coli

Tag:

His-GST

Molecular Weight:

78.2 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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