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ATP4A
ATPase, H+/K+ exchanging, alpha polypeptide
ATP4A belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes a catalytic alpha subunit of the gastric H+, K+-ATPase.
| Gene Name: | ATPase, H+/K+ exchanging, alpha polypeptide |
| Family/Subfamily: | Transporter , ATPase - P type, type IIC |
| Synonyms: | ATP4A, H(+)-K(+)-ATPase alpha subunit, ATP6A, Proton pump |
| Target Sequences: | NM_000704 NP_000695.2 P20648 |
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