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ATP5A1 / ATP Synthase Alpha

ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F1. Rotation of the central stalk against the surrounding alpha3beta3 subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites.

Gene Name: ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
Family/Subfamily: Transporter , ATPase - F type
Synonyms: ATP5A1, ATP5AL2, ATP5A, HATP1, Mitochondrial ATP synthase, MOM2, ORM, OMR, ATPM
Target Sequences: NM_004046 NP_004037.1 P25705

Publications (1)

1
Taurine Inhibits Glucocorticoid-Induced Bone Mitochondrial Injury, Preventing Osteonecrosis in Rabbits and Cultured Osteocytes. Hiroaki Hirata, Shusuke Ueda, Toru Ichiseki, Miyako Shimasaki, Yoshimichi Ueda, Ayumi Kaneuji, Norio Kawahara. International journal of molecular sciences. 2020 September;21: [Full Text Article] [PubMed:32962196] [PMC:PMC7555938] Related Antibodies: LS-B11269.

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Proteins (7)
Over-Expression Lysate (2)
Recombinant (5)
ATP5A1 / ATP Synthase Alpha (7)
No (7)
6His, N-terminus (1)
6His-SUMO, N-terminus (1)
GST (1)
His-SUMO (1)
Myc-DDK (Flag) (3)
Human (6)
293T Cells (1)
E. coli (2)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Yeast (1)
Purified (3)
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E. coli
His-SUMO
71.18 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
ATP5A1 / ATP Synthase Alpha Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
59.75 kDa
100 µg/$494
ATP5A1 / ATP Synthase Alpha Protein - 12.5% SDS-PAGE of human ATP5A1 stained with Coomassie Blue
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Wheat Germ Extract
GST
86.2 kDa
2 µg/$439
ATP5A1 / ATP Synthase Alpha Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
59.75 kDa
20 µg/$150
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HEK 293 Cells
Myc-DDK (Flag)
55.2 kDa
20 µg/$1,107
ATP5A1 / ATP Synthase Alpha Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Yeast
6His, N-terminus
100 µg/$446; 20 µg/$336; 1 mg/$1,460
ATP5A1 / ATP Synthase Alpha Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His-SUMO, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).