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Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha3beta3 subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
Gene Name: | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6 |
Family/Subfamily: | Transporter , ATPase - F type |
Synonyms: | ATP5J, ATP5, ATP5A, Coupling factor 6, CF6, F6, ATPase subunit F6, ATPM, ATP5PF, ATP synthase-coupling factor 6, mitochondrial, P18859, ATP5J_HUMAN |
Target Sequences: | NM_001685 NP_001676.2 |
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