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ATP6V1C1

ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1

ATP6V1C1 is a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D.

Gene Name: ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
Family/Subfamily: Transporter , ATPase - V type
Synonyms: ATP6V1C1, H+ -ATPase C subunit, VATC, Vma5, V-ATPase subunit C 1, ATP6C, ATP6D, V-ATPase C subunit, Vacuolar proton pump C subunit
Target Sequences: NM_001695 NP_001686.1 P21283

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Products
Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
ATP6V1C1 (5)
No (5)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (3)
Human (4)
293T Cells (1)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (1)
ATP6V1C1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
ATP6V1C1 Protein - Purified recombinant protein ATP6V1C1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
43.8 kDa
20 µg/$1,107
ATP6V1C1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
43.8 kDa
100 µg/$494
ATP6V1C1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
43.8 kDa
20 µg/$150
ATP6V1C1 Protein - 12.5% SDS-PAGE of human ATP6V1C1 stained with Coomassie Blue
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Wheat Germ Extract
GST
70.3 kDa
10 µg/$479; 25 µg/$670
Viewing 1-5 of 5 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).