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ATXN1 / SCA1

ataxin 1

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 41-81 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been found for this gene.

Gene Name: ataxin 1
Synonyms: ATXN1, ATX1, Ataxin 1, D6S504E, Ataxin-1, SCA1
Target Sequences: NM_000332 NP_000323.2 P54253

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Products
ELISA Kits (16)
Competitive EIA (1)
Sandwich (12)
Sandwich CLIA (3)
ATXN1 / SCA1 (16)
Human (4)
Mouse (3)
Rat (3)
Chicken (1)
Guinea pig (1)
Monkey (1)
Porcine (1)
Rabbit (1)
Sheep (1)
12 x 8-Well Microstrips (3)
96-Well Microplate (3)
96-Well Strip Plate (10)
No (16)
Plasma (10)
Serum (10)
Tissue Homogenates (3)
ATXN1 / SCA1 ELISA Kit
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Sandwich
96-Well Microplate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
ATXN1 / SCA1 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
ATXN1 / SCA1 ELISA Kit
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Sandwich
96-Well Microplate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
ATXN1 / SCA1 ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Human
1 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
ATXN1 / SCA1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
ATXN1 / SCA1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
ATXN1 / SCA1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
ATXN1 / SCA1 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
62.5 - 4000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
ATXN1 / SCA1 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Mouse
7.813 - 500 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
ATXN1 / SCA1 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Rat
62.5 - 4000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
ATXN1 / SCA1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Guinea pig
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
ATXN1 / SCA1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Chicken
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
ATXN1 / SCA1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
ATXN1 / SCA1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
ATXN1 / SCA1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Porcine
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
ATXN1 / SCA1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Sheep
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$691
Viewing 1-16 of 16 product results


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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).