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AVPR1B

arginine vasopressin receptor 1B

AVPR1B acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known.

Gene Name: arginine vasopressin receptor 1B
Family/Subfamily: GPCR , Vasopressin/oxytocin
Synonyms: AVPR1B, AVPR3, V1bR, AVPR V1b, AVPR V3, V1b receptor, V1b vasopressin receptor, Vasopressin V1b receptor, Vasopressin V3 receptor, VPR3
Target Sequences: AF030512 BAA06621.1 P47901

Publications (2)

1
Proinflammatory role of vasopressin through V1b receptors in hapten-induced experimental colitis in rodents: implication in IBD. Ferrier L, Serradeil-Le Gal C, Schulte AM, Vasina V, Gaultier E, Schroedel S, Ursino MG, Chaumaz G, Pascal M, De Ponti F, Bueno L. American journal of physiology. Gastrointestinal and liver physiology. 2010 299:G1298-307. (IHC-P; Human) [PubMed:20864658] Related Antibodies: LS-A3739.
2
Impact of USP8 Gene Mutations on Protein Deregulation in Cushing Disease. Isabel Weigand, Lisanne Knobloch, Jörg Flitsch, Wolfgang Saeger, Camelia M Monoranu, Kerstin Höfner, Sabine Herterich, Roman Rotermund, Cristina L Ronchi, Michael Buchfelder, Markus Glatzel, Christian Hagel, Martin Fassnacht, Timo Deutschbein, Silviu Sbiera. The Journal of clinical endocrinology and metabolism. 2019 July;104:2535-2546. [Full Text Article] [PubMed:30844069] Related Antibodies: LS-A3737.

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AVPR1B Protein
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E. coli
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13.1 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
AVPR1B Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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46.8 kDa
100 µg/$710
AVPR1B Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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46.8 kDa
20 µg/$215
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).