AVPR2 / V2R

arginine vasopressin receptor 2

AVPR2 / V2R is the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing.

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Proteins (3)

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Over-Expression Lysate (2)

Recombinant (1)

Target

AVPR2 / V2R (3)

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6His-SUMO, N-terminus (1)

Myc-DDK (Flag) (2)

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Human (1)

Pig (1)

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293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

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AVPR2 / V2R Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G98895

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.1 kDa

Price:

100 µg/$494

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Human AVPR2 / V2R Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79543

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.1 kDa

Price:

20 µg/$150

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Pig AVPR2 / V2R Protein (Recombinant 6His-SUMO, N-terminus) (aa292-370) - LS-G56114

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,679; 100 µg/$598; 20 µg/$405

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