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Infectious Disease
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Location
Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
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Customer Service: (800) 227-6666 / (650) 697-3600
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AXIN1 / Axin-1
axin 1
Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.
| Gene Name: | axin 1 |
| Synonyms: | AXIN1, Axis inhibitor 1, AXIN, Axin 1, Axis inhibition protein 1, Fused, mouse, homolog of, HAxin, PPP1R49, Axin-1 |
| Target Sequences: | AF009674 AAC51624.1 O15169 |
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(80)
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AXIN1 / Axin-1
(95)
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AXIN1 / Axin-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
AXIN1 / Axin-1 Goat anti-Human Polyclonal (aa850-862) Antibody
Zebrafish, Horse, Bat, Rat, Hamster, Mouse, Bovine, Human, Monkey
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µg/$485
Sandwich
96-Well Strip Plate
Human
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$587
AXIN1 / Axin-1 Mouse anti-Human Monoclonal (4E9F1) Antibody
Human
ELISA, Flo, ICC, WB
Unconjugated
100 µl/$459
Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
AXIN1 / Axin-1 Rabbit anti-Human Polyclonal (aa710-738) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
E. coli
6His, N-terminus
27.2 kDa
10 µg/$279; 50 µg/$425; 100 µg/$680; 200 µg/$850; 1 mg/$1,944; 500 µg/$1,490; 5 mg/$2,969; 2 mg/$2,131
AXIN1 / Axin-1 Rabbit anti-Human Polyclonal (aa330-359) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
![AXIN1 / Axin-1 Antibody - Immunofluorescence of monoclonal antibody to AXIN1 on HeLa cell . [antibody concentration 10 ug/ml]](https://lsbio-7d62.kxcdn.com/image2/axin1-axin-1-antibody-clone-2b11-ls-c198545/147151_5005245.jpg)
AXIN1 / Axin-1 Mouse anti-Human Monoclonal (2B11) Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$423
AXIN1 / Axin-1 Rabbit anti-Human Polyclonal (aa710-738) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
AXIN1 / Axin-1 Rabbit anti-Human Polyclonal (aa710-738) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
AXIN1 / Axin-1 Rabbit anti-Human Polyclonal (aa710-738) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
AXIN1 / Axin-1 Rabbit anti-Human Polyclonal (aa710-738) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
AXIN1 / Axin-1 Rabbit anti-Human Polyclonal (aa710-738) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
AXIN1 / Axin-1 Rabbit anti-Human Polyclonal (aa710-738) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
AXIN1 / Axin-1 Rabbit anti-Human Polyclonal Antibody
Rat, Human
IHC, WB
Unconjugated
100 µg/$442
AXIN1 / Axin-1 Mouse anti-Human Monoclonal (4F10G1) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$459
AXIN1 / Axin-1 Rabbit anti-Human Polyclonal (Biotin) Antibody
Rat, Human
IHC, WB
Biotin Conjugated
100 µg/$475
AXIN1 / Axin-1 Rabbit anti-Human Polyclonal (FITC) Antibody
Rat, Human
IHC, WB
FITC Conjugated
100 µg/$472
AXIN1 / Axin-1 Rabbit anti-Human Polyclonal (APC) Antibody
Rat, Human
IHC, WB
APC Conjugated
100 µg/$478
AXIN1 / Axin-1 Rabbit anti-Human Polyclonal (PerCP) Antibody
Rat, Human
IHC, WB
PerCP Conjugated
100 µg/$478
AXIN1 / Axin-1 Rabbit anti-Human Polyclonal (RPE) Antibody
Rat, Human
IHC, WB
RPE Conjugated
100 µg/$477
AXIN1 / Axin-1 Rabbit anti-Human Polyclonal (Atto 488) Antibody
Rat, Human
IHC, WB
Atto 488 Conjugated
100 µg/$479
AXIN1 / Axin-1 Rabbit anti-Human Polyclonal (Atto 594) Antibody
Rat, Human
IHC, WB
Atto 594 Conjugated
100 µg/$479
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