AXIN1 / Axin-1

axin 1

Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.

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Products

Proteins (9)

Type

Over-Expression Lysate (4)

Recombinant (5)

Target

AXIN1 / Axin-1 (9)

Publications

No (9)

Tag

6His, N-terminus (1)

GST, N-terminus (1)

His-T7 (2)

Myc-DDK (Flag) (5)

Species

Human (5)

Mouse (1)

Rat (1)

Source

293T Cells (2)

E. coli (3)

HEK 293 Cells (3)

Wheat Germ Extract (1)

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Mouse AXIN1 / Axin-1 Protein (Recombinant 6His, N-terminus) (aa654-863) - LS-G14839

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

27.2 kDa

Price:

10 µg/$279; 50 µg/$425; 100 µg/$680; 200 µg/$850; 1 mg/$1,944; 500 µg/$1,490; 5 mg/$2,969; 2 mg/$2,131

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Human AXIN1 / Axin-1 Protein (Recombinant GST, N-terminus) (aa643-740) - LS-G60682

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human AXIN1 / Axin-1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80155

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

95.5 kDa

Price:

20 µg/$215

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Human AXIN1 / Axin-1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80156

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

91.5 kDa

Price:

20 µg/$150

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AXIN1 / Axin-1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G104546

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

91.5 kDa

Price:

100 µg/$494

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Human AXIN1 / Axin-1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67562

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

91.5 kDa

Price:

20 µg/$1,107

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AXIN1 / Axin-1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117294

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

95.5 kDa

Price:

100 µg/$710

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Human AXIN1 / Axin-1 Protein (Recombinant His-T7) (aa653-862) - LS-G14837

Source:

E. coli

Tag:

His-T7

Molecular Weight:

27.6 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Rat AXIN1 / Axin-1 Protein (Recombinant His-T7) (aa618-827) - LS-G14844

Source:

E. coli

Tag:

His-T7

Molecular Weight:

27.4 kDa

Price:

10 µg/$287; 50 µg/$480; 100 µg/$767; 200 µg/$957; 1 mg/$2,089; 500 µg/$1,617; 5 mg/$3,825

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