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AXIN2 / Axin 2
axin 2
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
| Gene Name: | axin 2 |
| Synonyms: | AXIN2, AXIL, Axin-2, Axis inhibition protein 2, Axin 2, Axin-like protein, Conductin |
| Target Sequences: | NM_004655 NP_004646.3 Q9Y2T1 |
Publications (1)
1
Maternal Huluwa dictates the embryonic body axis through ß-catenin in vertebrates. Yan L, Chen J, Zhu X, Sun J, Wu X, Shen W, Zhang W, Tao Q, Meng A. Science (New York, N.Y.). 2018 November;362: [Full Text Article]
[PubMed:30467143]
Related Antibodies: LS-C345085.
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AXIN2 / Axin 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC-P, WB
Unconjugated
0.05 mg/$460
AXIN2 / Axin 2 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
AXIN2 / Axin 2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$730
AXIN2 / Axin 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, WB
Unconjugated
50 µl/$286; 100 µl/$321; 200 µl/$386
AXIN2 / Axin 2 Rabbit anti-Human Monoclonal (Pro556) Antibody
Human
ELISA, IP, WB
Unconjugated
100 µl/$688
Sandwich
96-Well Strip Plate
Mouse
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
AXIN2 / Axin 2 Rabbit anti-Human Polyclonal (aa816-843) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
E. coli
His
32.7 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
Sandwich CLIA
12 x 8-Well Microstrips
Mouse
7.813 - 500 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
AXIN2 / Axin 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
AXIN2 / Axin 2 Rabbit anti-Human Polyclonal (aa350-631) Antibody
Human
IHC-P, WB
Unconjugated
50 µl/$460
AXIN2 / Axin 2 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Rabbit, Guinea pig, Bovine, Rat, Pig, Human
WB
HRP Conjugated
100 µl/$469
AXIN2 / Axin 2 Rabbit anti-Human Polyclonal (aa816-843) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
200 µl/$734
AXIN2 / Axin 2 Rabbit anti-Human Polyclonal (aa816-843) (Biotin) Antibody
Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200 µl/$952
AXIN2 / Axin 2 Rabbit anti-Human Polyclonal (aa816-843) (FITC) Antibody
Human
ELISA, Flo, IHC, WB
FITC Conjugated
200 µl/$952
AXIN2 / Axin 2 Rabbit anti-Human Polyclonal (aa816-843) (APC) Antibody
Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$952
AXIN2 / Axin 2 Rabbit anti-Human Polyclonal (aa816-843) (PE) Antibody
Human
ELISA, Flo, IHC, WB
PE Conjugated
200 µl/$952
AXIN2 / Axin 2 Rabbit anti-Human Polyclonal (aa816-843) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
Sandwich
96-Well Microplate
Mouse
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
AXIN2 / Axin 2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
AXIN2 / Axin 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
AXIN2 / Axin 2 Mouse anti-Human Monoclonal (3B6) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
AXIN2 / Axin 2 Rabbit anti-Human Polyclonal Antibody
Rat, Human
IHC, WB
Unconjugated
100 µg/$442
AXIN2 / Axin 2 Rabbit anti-Human Polyclonal Antibody
Rat, Human
IHC, WB
Unconjugated
100 µg/$442
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