AZIN1

antizyme inhibitor 1

AZIN1 belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene.

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Proteins (10)

Type

Over-Expression Lysate (4)

Recombinant (6)

Target

AZIN1 (10)

Publications

No (10)

Tag

DDK,C-terminus (1)

GST (1)

GST, N-terminus (1)

His-T7 (2)

Myc-DDK (Flag) (5)

Species

Human (7)

Rat (1)

Source

293T Cells (2)

E. coli (2)

HEK 293 Cells (3)

Sf9 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human AZIN1 Protein (Recombinant GST) (Full Length) - LS-G33830

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

75.9 kDa

Price:

10 µg/$479; 25 µg/$670

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Human AZIN1 Protein (Recombinant GST, N-terminus) (aa339-447) - LS-G62502

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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AZIN1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G106492

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

49.4 kDa

Price:

100 µg/$494

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AZIN1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101358

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

49.4 kDa

Price:

100 µg/$494

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Human AZIN1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67965

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

49.4 kDa

Price:

20 µg/$1,107

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Human AZIN1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81090

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

49.4 kDa

Price:

20 µg/$150

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Human AZIN1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81091

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

49.4 kDa

Price:

20 µg/$150

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Human AZIN1 Protein (Recombinant DDK,C-terminus) - LS-G142458

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

49.4 kDa

Price:

20 µg/$677

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Human AZIN1 Protein (Recombinant His-T7) (aa5-290) - LS-G24771

Source:

E. coli

Tag:

His-T7

Molecular Weight:

34.8 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$645; 200 µg/$805; 1 mg/$1,881; 500 µg/$1,435; 5 mg/$2,844; 2 mg/$2,065

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Rat AZIN1 Protein (Recombinant His-T7) (aa1-280) - LS-G24772

Source:

E. coli

Tag:

His-T7

Molecular Weight:

34.3 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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