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BAFF / TNFSF13B

tumor necrosis factor (ligand) superfamily, member 13b

Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF (for B cell Activating Factor belonging to the TNF Family), BLyS (for B Lymphocyte Stimulator), TALL-1 (for TNF- and ApoL-related Leukocyte-expressed Ligand), and THANK (for TNF Homologue that Activate Apoptosis, NF-kB and c-jun N-terminal Kinase). BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. Three receptors for BAFF were recently identified and designated TACI, BCMA and BAFF-R. BAFF and its receptors are essential for B cell development, survival, and humoral immune responses. BAFF is involved in the development of autoimmune diseases including systemic lupus erythaematosus and rheumatoid arthritis.

Gene Name: tumor necrosis factor (ligand) superfamily, member 13b
Family/Subfamily: TNF , not assigned-TNF
Synonyms: TNFSF13B, B-cell-activating factor, BAFF, ApoL related ligand TALL-1, B-lymphocyte stimulator, CD257, BLYS, Delta4 BAFF, Delta BAFF, TALL-1, TALL1, ZTNF4, THANK, B lymphocyte stimulator, CD257 antigen, TNFSF20
Target Sequences: NM_006573 NP_006564.1 Q9Y275

☰ Filters
Products
Proteins (30)
Over-Expression Lysate (2)
Recombinant (28)
BAFF / TNFSF13B (30)
Animal-free (1)
No (30)
6His, N-terminus (1)
DDK (Flag) (2)
Fc (2)
Fc, N-terminus (2)
GST (1)
GST, N-terminus (1)
His (4)
His, N-Terminal (1)
His-DDK (Flag), N-terminus (1)
His-SUMO (1)
Human IgG1 Fc (1)
Mouse IgG1 Fc, N-terminus (1)
Myc-DDK (Flag) (3)
Human (25)
Mouse (4)
293T Cells (1)
CHO Cells (4)
E. coli (12)
HEK 293 Cells (5)
Human (2)
Human Cells (2)
Mammalian Cells (2)
Wheat Germ Extract (2)
Purified (7)
Low endotoxin level (18)
Biologically active (7)
Animal-free (1)
Select
Mammalian Cells
Fc, N-terminus
Less than 0.1 ng/mL (Less than 1 EU/µg) (determined by LAL method).
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
BAFF / TNFSF13B Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
BAFF / TNFSF13B Protein - Recombinant Mouse TNFSF13B/BAFF/CD257 (N-mFc)
Select
Human
Mouse IgG1 Fc, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
46.9 kDa
10 µg/$290; 50 µg/$446
BAFF / TNFSF13B Protein
Select
E. coli
His, N-Terminal
Less than 0.1 EU/µg protein (determined by LAL method).
19.2 kDa
100 µg/$677
BAFF / TNFSF13B Protein
Select
HEK 293 Cells
His-DDK (Flag), N-terminus
19 kDa
20 µg/$1,107
BAFF / TNFSF13B Protein - Recombinant Human TNFSF13B/BAFF/CD257 (N-6His)
Select
Human
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
19.3 kDa
10 µg/$331; 50 µg/$593
Select
HEK 293 Cells
Fc
43.9 kDa
10 µg/$377; 50 µg/$752; 100 µg/$1,099
BAFF / TNFSF13B Protein
Select
E. coli
His-SUMO
39.7 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Select
CHO Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
17 kDa (SDS-PAGE)
50 µg/$402; 10 µg/$262; 1 mg/$2,171
BAFF / TNFSF13B Protein - Purified recombinant protein TNFSF13B was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
31 kDa
20 µg/$1,107
Select
Human Cells
None
Less than 1.0 EU/µg protein (determined by LAL method).
17 kDa
100 µg/$1,159; 1 mg/$5,413
Select
E. coli
None
17.2 kDa
20 µg/$360; 100 µg/$728
BAFF / TNFSF13B Protein
Select
E. coli
None
Biologically active
17.2 kDa
5 µg/$282; 100 µg/$1,466; 500 µg/$3,025
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
17.0 kDa
5 µg/$268; 20 µg/$349
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
5 µg/$282; 20 µg/$370
BAFF / TNFSF13B Protein - Recombinant B-Cell Activating Factor By SDS-PAGE
Select
E. coli
His
27.7 kDa
10 µg/$265; 50 µg/$347; 100 µg/$545; 200 µg/$682; 1 mg/$1,690; 500 µg/$1,270; 5 mg/$2,637; 2 mg/$1,866
BAFF / TNFSF13B Protein - Recombinant B-Cell Activating Factor By SDS-PAGE
Select
E. coli
His
20.6 kDa
10 µg/$259; 50 µg/$331; 100 µg/$482; 200 µg/$602; 1 mg/$1,553; 500 µg/$1,156; 5 mg/$2,481; 2 mg/$1,723
BAFF / TNFSF13B Protein - 12.5% SDS-PAGE of human TNFSF13B stained with Coomassie Blue
Select
Wheat Germ Extract
GST
57.09 kDa
10 µg/$479; 25 µg/$670
BAFF / TNFSF13B Protein
Select
E. coli
His
Less than 1.0 EU/µg protein (determined by LAL method).
100 µg/$411; 500 µg/$985; 20 µg/$276
Select
HEK 293 Cells
DDK (Flag)
Less than 0.01 EU/µg protein (determined by LAL method).
~26kDa (SDS-PAGE)
10 µg/$330
BAFF / TNFSF13B Protein - Coomassie blue staining of BAFF, Soluble (human) (60-mer) (AG-40B-0112) under reducing conditions (shows the size of the monomer).
Select
E. coli
His
Less than 0.01 EU/µg protein (determined by LAL method).
~19kDa (under reduced conditions)~1100kDa (under native conditions)
10 µg/$386
Select
E. coli
DDK (Flag)
Less than 0.01 EU/µg protein (determined by LAL method).
~23kDa (SDS-PAGE)
10 µg/$365
BAFF / TNFSF13B Protein - Restoration of the splenic T and B cell architecture in Fc-BAFF injected BAFFdeficient mice. BAFF deficient mice were injected at day 0 with 100mg BAFF (human):Fc (human) (AG-40B-0120) intravenously and at day 14 with 50mg BAFF (human):Fc (human) intraperitoneal. At day 21, injected BAFFdeficient mice were sacrificed together with WT and control BAFFdeficient mice and splenic T and B cell architecture was analyzed by fluorescence microscopy on cryosections. A, Spleen sections of WT (left picture), BAFF deficient (middle picture) or injected BAFFdeficient mice (right picture) were stained for IgM (red) and CD90 (green). (B) Spleen sections of the same mice were stained for IgM (green) and MOMA (red).
Select
CHO Cells
Human IgG1 Fc
Less than 0.01 EU/µg protein (determined by LAL method).
50kDa or 100kDa or 300kDa
10 µg/$344
Select
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
43.7 kDa
100 µg/$767; 1 mg/$4,063
Select
Mammalian Cells
Fc, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
43.3 kDa
10 µg/$288; 50 µg/$436
Viewing 1-25 of 30 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).