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BCL2 / Bcl-2

B-cell CLL/lymphoma 2

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).

Gene Name:	B-cell CLL/lymphoma 2
Family/Subfamily:	Apoptosis
Synonyms:	BCL2, Apoptosis regulator Bcl-2, B-cell CLL/lymphoma 2, B-cell lymphoma protein 2, Bcl-2, PPP1R50
Target Sequences:	NM_000633 NP_000624.2 P10415

Publications (10)

BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents. Deng J, Carlson N, Takeyama K, Dal Cin P, Shipp M, Letai A. Cancer cell. 2007 12:171-85. (IP) [PubMed:17692808]

Natural diterpenoid compound elevates expression of Bim protein, which interacts with antiapoptotic protein Bcl-2, converting it to proapoptotic Bax-like molecule. Zhao L, He F, Liu H, Zhu Y, Tian W, Gao P, He H, Yue W, Lei X, Ni B, Wang X, Jin H, Hao X, Lin J, Chen Q. The Journal of biological chemistry. 2012 287:1054-65. [PubMed:22065578] [PMC:PMC3256916] Related Antibodies: LS-C98842.

The Protective Properties of the Strawberry (Fragaria ananassa) against Carbon Tetrachloride-Induced Hepatotoxicity in Rats Mediated by Anti-Apoptotic and Upregulation of Antioxidant Genes Expression Effects. Hamed SS, Al-Yhya NA, El-Khadragy MF, Al-Olayan EM, Alajmi RA, Hassan ZK, Hassan SB, Abdel Moneim AE. Frontiers in physiology. 2016 August;7:325. [Full Text Article] [PubMed:27547187] [PMC:PMC4974471]

Bmi-1 in gallbladder carcinoma: Clinicopathology and mechanism of regulation of human gallbladder carcinoma proliferation. Jiao K, Jiang W, Zhao C, Su D, Zhang H. Oncology letters. 2019 August;18:1365-1371. [Full Text Article] [PubMed:31423199] [PMC:PMC6607302] Related Antibodies: LS-B6548.

Recognition of microbial viability via TLR8 drives TFH cell differentiation and vaccine responses. Matteo Ugolini, Jenny Gerhard, Sanne Burkert, Kristoffer Jarlov Jensen, Philipp Georg, Friederike Ebner, Sarah M Volkers, Shruthi Thada, Kristina Dietert, Laura Bauer, Alexander Schäfer, Elisa T Helbig, Bastian Opitz, Florian Kurth, Saubashya Sur, Nickel Dittrich, Sumanlatha Gaddam, Melanie L Conrad, Christine S Benn, Ulrike Blohm, Achim D Gruber, Andreas Hutloff, Susanne Hartmann, Mark V Boekschoten, Michael Müller, Gregers Jungersen, Ralf R Schumann, Norbert Suttorp, Leif E Sander. Nature immunology. 2018 April;19:386-396. [Full Text Article] [PubMed:29556002]

The Beneficial Effect of Eco-Friendly Green Nanoparticles Using Garcinia mangostana Peel Extract against Pathogenicity of Listeria monocytogenes in Female BALB/c Mice. Afrah F Alkhuriji, Nada A Majrashi, Suliman Alomar, Manal F El-Khadragy, Manal A Awad, Alaa R Khatab, Hany M Yehia. Animals: an open access journal from MDPI. 2020 Mar;10:573. [Full Text Article] [PubMed:32235366] [PMC:PMC7222409]

Translational control of Bcl-2 promotes apoptosis of gastric carcinoma cells. Shuangfen Tao, Jianchun Gu, Qing Wang, Leizhen Zheng. BMC cancer. 2021 Jan;21:12. [Full Text Article] [PubMed:33402109] [PMC:PMC7786514]

LncRNA H19 aggravates TNF-a-induced inflammatory injury via TAK1 pathway in MH7A cells. Jialiang Yang, Yixuan Li, Lili Wang, Zhenchun Zhang, Zunzhong Li, Qian Jia. BioFactors (Oxford, England). 2020 September;46:813-820. [Full Text Article] [PubMed:32525617] Related Antibodies: LS-C343557.

METTL3 boosts mitochondrial fission and induces cardiac fibrosis after ischemia/reperfusion injury. Li Ma, Xing Chang, Jing Gao, Ying Zhang, Ye Chen, Hao Zhou, Na Zhou, Na Du, Jiamin Li, Jiachen Bi, Ziyue Chen, Xinxin Chen, Qingyong He. International journal of biological sciences. 2024 January;20:433-445. [Full Text Article] [PubMed:38169612] [PMC:PMC10758110]

Lung molecular and histological changes in type 2 diabetic rats and its improvement by high-intensity interval training. Mohammad Amin Rajizadeh , Kayvan Khoramipour , Siyavash Joukar, Fatemeh Darvishzadeh-Mahani, Maryam Iranpour, Mohammad Abbas Bejeshk, Maryam Doustaki Zaboli. BMC pulmonary medicine. 2024 January;24:37. [Full Text Article] [PubMed:38233819] [PMC:PMC10792831]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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