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BIRC3 / cIAP2
baculoviral IAP repeat containing 3
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.
| Gene Name: | baculoviral IAP repeat containing 3 |
| Family/Subfamily: | Apoptosis , Not assigned-Other |
| Synonyms: | BIRC3, AIP1, API2, Apoptosis inhibitor 2, CIAP2, Hiap-1, HIAP1, IAP homolog C, Mammalian IAP homolog C, MIHC, IAP-1, IAP1, RING finger protein 49, RNF49, C-IAP2, HAIP1, MALT2 |
| Target Sequences: | NM_001165 NP_001156.1 Q13489 |
Publications (3)
1
Requirement of the human T-cell leukemia virus (HTLV-1) tax-stimulated HIAP-1 gene for the survival of transformed lymphocytes. Wldele K, Silbermann K, Schneider G, Ruckes T, Cullen BR, Grassmann R. Blood. 2006 107:4491-9. (WB)
[PubMed:16467195]
2
Cellular inhibitor of apoptosis 1 (cIAP-1) degradation by caspase 8 during TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. Guicciardi ME, Mott JL, Bronk SF, Kurita S, Fingas CD, Gores GJ. Experimental cell research. 2011 317:107-16.
[PubMed:20951133]
[PMC:PMC2991414]
3
Hedgehog inhibition promotes a switch from Type II to Type I cell death receptor signaling in cancer cells. Kurita S, Mott JL, Cazanave SC, Fingas CD, Guicciardi ME, Bronk SF, Roberts LR, Fernandez-Zapico ME, Gores GJ. PloS one. 2011 6:e18330.
[PubMed:21483830]
[PMC:PMC3069071]
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BIRC3 / cIAP2
(74)
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BIRC3 / cIAP2 Goat anti-Human Polyclonal (aa101-111) Antibody
Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
BIRC3 / cIAP2 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
BIRC3 / cIAP2 Mouse anti-Human Monoclonal (aa255-529) (Carrier-free) (OTI1A9) Antibody
Human
Flo, WB
Unconjugated, Carrier-free
100 µg/$511
BIRC3 / cIAP2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
50 µg/$294; 100 µg/$360
BIRC3 / cIAP2 Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ELISA
Unconjugated, Preservative Free
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
E. coli
6His, N-terminus
42 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365; 500 µg/$949
BIRC3 / cIAP2 Mouse anti-Human Monoclonal (aa2-604) (1D4B) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$930
BIRC3 / cIAP2 Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ELISA, WB
Unconjugated, Preservative Free
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
BIRC3 / cIAP2 Rabbit anti-Human Polyclonal (Preservative Free) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated, Preservative Free
50 µg/$343
BIRC3 / cIAP2 Goat anti-Human Polyclonal (aa109-118) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
BIRC3 / cIAP2 Mouse anti-Human Monoclonal (aa255-529) (OTI2B7) Antibody
Human
WB
Unconjugated
100 µl/$434
BIRC3 / cIAP2 Mouse anti-Human Monoclonal (OTI2G7) Antibody
Human
WB
Unconjugated
100 µl/$434
BIRC3 / cIAP2 Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ELISA
Unconjugated, Preservative Free
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
BIRC3 / cIAP2 Rabbit anti-Human Polyclonal (aa59-88) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
BIRC3 / cIAP2 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
0.1 ml/$386
BIRC3 / cIAP2 Rabbit anti-Human Polyclonal (aa100-200) (Biotin) Antibody
Human
ICC, IF, IHC, IHC-P, WB
Biotin Conjugated
0.1 ml/$416
BIRC3 / cIAP2 Rabbit anti-Human Polyclonal (aa100-200) (DY650) Antibody
Human
ICC, IF, IHC, IHC-P, WB
DY650 Conjugated
0.1 ml/$416
BIRC3 / cIAP2 Rabbit anti-Human Polyclonal (aa100-200) (DY488) Antibody
Human
ICC, IF, IHC, IHC-P, WB
DY488 Conjugated
0.1 ml/$416
BIRC3 / cIAP2 Rabbit anti-Human Polyclonal (aa100-200) (DY550) Antibody
Human
ICC, IF, IHC, IHC-P, WB
DY550 Conjugated
0.1 ml/$416
BIRC3 / cIAP2 Rabbit anti-Human Polyclonal (aa59-88) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
200 µl/$734
BIRC3 / cIAP2 Rabbit anti-Human Polyclonal (aa59-88) (Biotin) Antibody
Human
ELISA, IF, IHC, WB
Biotin Conjugated
200 µl/$952
BIRC3 / cIAP2 Rabbit anti-Human Polyclonal (aa59-88) (FITC) Antibody
Human
ELISA, ICC, IF, IHC, WB
FITC Conjugated
200 µl/$952
BIRC3 / cIAP2 Rabbit anti-Human Polyclonal (aa59-88) (APC) Antibody
Human
ELISA, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
BIRC3 / cIAP2 Rabbit anti-Human Polyclonal (aa59-88) (PE) Antibody
Human
ELISA, ICC, IF, IHC, WB
PE Conjugated
200 µl/$952
BIRC3 / cIAP2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$331
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