BIRC3 / cIAP2

baculoviral IAP repeat containing 3

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.

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Products

Proteins (8)

Type

Over-Expression Lysate (4)

Recombinant (4)

Target

BIRC3 / cIAP2 (8)

Publications

No (8)

Tag

6His, N-terminus (1)

GST (1)

Myc-DDK (Flag) (6)

Species

Human (5)

Mouse (1)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (4)

Wheat Germ Extract (1)

Purification

Purified (2)

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Mouse BIRC3 / cIAP2 Protein (Recombinant 6His, N-terminus) (Asn2-Ala376) - LS-G26452

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

42 kDa

Price:

10 µg/$265; 50 µg/$315; 100 µg/$365; 500 µg/$949

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Human BIRC3 / cIAP2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66018

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

68.2 kDa

Price:

20 µg/$1,107

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Human BIRC3 / cIAP2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66019

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

68.2 kDa

Price:

20 µg/$1,107

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BIRC3 / cIAP2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G104044

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

68.2 kDa

Price:

100 µg/$494

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Human BIRC3 / cIAP2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76760

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

68.2 kDa

Price:

20 µg/$150

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Human BIRC3 / cIAP2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76761

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

68.2 kDa

Price:

20 µg/$150

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BIRC3 / cIAP2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118745

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

68.2 kDa

Price:

100 µg/$494

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Human BIRC3 / cIAP2 Protein (Recombinant GST) (Full Length) - LS-G27477

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

94.8 kDa

Price:

10 µg/$479; 25 µg/$670

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