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BLC / CXCL13
chemokine (C-X-C motif) ligand 13
B lymphocyte chemoattractant, independently cloned and named Angie, is an antimicrobial peptide and CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles.
| Gene Name: | chemokine (C-X-C motif) ligand 13 |
| Family/Subfamily: | Intercrine , Intercrine alpha |
| Synonyms: | CXCL13, ANGIE, ANGIE2, BLC, B cell-attracting chemokine 1, BCA-1, BCA1, C-X-C motif chemokine 13, SCYB13, Small-inducible cytokine B13, B lymphocyte chemoattractant, B-cell chemoattractant, B-cell-attracting chemokine 1, B-lymphocyte chemoattractant, Blc chemoattractant, BLR1L, Chemoattractant blc, CXC chemokine BLC |
| Target Sequences: | NM_006419 NP_006410.1 O43927 |
Publications (2)
1
CXCL13 in idiopathic pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. Olsson KM, Olle S, Fuge J, Welte T, Hoeper MM, Lerch C, Maegel L, Haller H, Jonigk D, Schiffer L. Respiratory research. 2016 17:21. (WB; Human)
[Full Text Article]
[PubMed:26927848]
[PMC:PMC4770535]
Related Antibodies: LS-C104337.
2
Activated microglia promote invasion and barrier dysfunction of brain endothelial cells via regulating the CXCL13/CXCR5 axis. Qiaolei Zhang, Jinhong Jiang, Yonghua Liu, Guangli Ma, Xiaoqiu Wang, Bingmu Fang. Cell biology international. 2022 September;46:1510-1518. [Full Text Article]
[PubMed:35670241]
☰ Filters
Products
Proteins
(16)
Type
Over-Expression Lysate
(2)
Recombinant
(14)
Target
BLC / CXCL13
(16)
Publications
No
(16)
Tag
GST
(2)
His
(1)
His, N-Terminal
(1)
His-GST
(2)
Myc-DDK (Flag)
(2)
Species
Human
(11)
Mouse
(3)
Rat
(1)
Source
293T Cells
(1)
E. coli
(11)
HEK 293 Cells
(1)
Wheat Germ Extract
(2)
Purification
Purified
(11)
Low Endotoxin Level
Low endotoxin level
(6)
Biologically Active
Biologically active
(7)
E. coli
His, N-Terminal
12.2 kDa
10 µg/$277; 50 µg/$420; 100 µg/$670; 200 µg/$837; 1 mg/$1,928; 500 µg/$1,474; 5 mg/$2,927; 2 mg/$2,113
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
10.3 kDa
5 µg/$268; 20 µg/$349
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
9.8 kDa
5 µg/$268; 20 µg/$349
E. coli
None
Biologically active
10.3 kDa
5 µg/$282; 100 µg/$957; 500 µg/$1,747
E. coli
His-GST
36.8 kDa
10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164
E. coli
His-GST
41.9 kDa
10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198
Wheat Germ Extract
GST
39.1 kDa
2 µg/$439
Wheat Germ Extract
GST
35.31 kDa
10 µg/$479; 25 µg/$670
293T Cells
Myc-DDK (Flag)
12.5 kDa
20 µg/$150
HEK 293 Cells
Myc-DDK (Flag)
12.5 kDa
100 µg/$494
E. coli
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 72 amino acid recombinant protein has a predicted molecular mass of approximately 8.6 kD. The DTT-reduced protein migrates at approximately 12 kD, and the non-reduced protein migrates at approximately 15 kD by SDS-PAGE. The N-terminal amino acid is Va
10 µg/$291; 25 µg/$359; 100 µg/$744; 500 µg/$1,779
E. coli
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 78 amino acid recombinant protein has a predicted molecular mass of approximately 9.79 kD. The DTT-reduced and non-reduced protein migrate at approximately 15 and 13 kD by SDS-PAGE respectively. The N-terminal amino acid is Ile.
10 µg/$306; 25 µg/$375; 100 µg/$731; 500 µg/$1,614
E. coli
None
Biologically active
Less than 1 EU/µg (determined by LAL method).
10.3 kDa
1 mg/$2,653; 20 µg/$364
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~10 kDa
20 µg/$432; 1 mg/$4,915
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