c-Met

met proto-oncogene

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells.Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells.

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Products

Proteins (22)

Type

Over-Expression Lysate (4)

Recombinant (18)

Target

c-Met (22)

Application

Bind (1)

ELISA (1)

Func (1)

SDS-PAGE (1)

Publications

No (22)

Tag

6His, C-terminus (5)

6His, N-terminus (1)

DDK (Flag)-His, C-terminus (1)

Fc (1)

Fc, C-terminus (3)

GST, N-terminus (1)

His (2)

His-GST (1)

His-T7 (1)

Human IgG Fc, C-terminus (1)

Myc-DDK (Flag) (5)

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Species

Human (17)

Mouse (3)

Source

293T Cells (2)

Baculovirus (1)

E. coli (2)

HEK 293 Cells (7)

Human Cells (4)

Mammalian Cells (5)

Wheat Germ Extract (1)

Purification

Purified (6)

Low Endotoxin Level

Low endotoxin level (12)

Biologically Active

Biologically active (2)

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Human c-Met Protein (Recombinant 6His, C-terminus) - LS-G137063

Source:

E. coli

Tag:

6His, C-terminus

Molecular Weight:

59.4 kDa

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human c-Met Protein (Recombinant 6His, C-terminus) (Glu25-Thr932) - LS-G51887

Source:

HEK 293 Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

102.5kD

Price:

10 µg/$248; 50 µg/$321; 500 µg/$905; 1 mg/$1,203

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Human c-Met Protein (Recombinant 6His, C-terminus) (Glu25-Gly519) - LS-G40296

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

56.9kD

Price:

10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157

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Mouse c-Met Protein (Recombinant Human IgG Fc, C-terminus) (Met1-Asn929) - LS-G49567

Source:

HEK 293 Cells

Tag:

Human IgG Fc, C-terminus

Application:

Bind ELISA Func SDS-PAGE

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant mouse Met/Fc chimera is a disulfide-linked homodimer of the Met which is a heterodimer composed of the proteolytically cleaved a and ß subunits. Each a and ß together with the C-terminal Fc tag consists of 1146 amino acids and has a predicted molecular mass of 128 (a =32 + Fc tagged ß=96) kDa. The apparent molecular mass of the rm MET/Fc heterodimer thus is approximately 43 kDa and 115-120 kDa respectively in SDS-PAGE under reducing conditions due to glycosylation.

Price:

100 µg/$410; 1 mg/$1,745

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Human c-Met Protein (Recombinant Fc, C-terminus) (Glu25-Thr932) - LS-G51888

Source:

Human Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

128.4kD

Price:

10 µg/$248; 50 µg/$321; 500 µg/$905; 1 mg/$1,203

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Human c-Met Protein (Recombinant GST, N-terminus) (aa26-125) - LS-G59227

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human c-Met Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65865

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

153 kDa

Price:

20 µg/$1,107

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c-Met Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G98978

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

155.54 kDa

Price:

100 µg/$710

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Mouse c-Met Protein (Recombinant Fc) (Met1-Asn929) - LS-G98217

Source:

Human Cells

Tag:

Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

128 kDa

Price:

100 µg/$661; 1 mg/$3,499

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Human c-Met Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76427

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

155.54 kDa

Price:

20 µg/$215

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Human c-Met Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76428

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

157.71 kDa

Price:

20 µg/$215

Select

c-Met Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G124652

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

157.71 kDa

Price:

100 µg/$710

Select

Human c-Met Protein (Recombinant Fc, C-terminus) - LS-G136779

Source:

Mammalian Cells

Tag:

Fc, C-terminus

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

128.4 kDa

Price:

50 µg/$356; 10 µg/$259; 1 mg/$1,470; 500 µg/$1,147

Select

Human c-Met Protein (Recombinant Fc, C-terminus) (Glu25-Thr932) - LS-G138720

Source:

Mammalian Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

128.4 kDa

Price:

10 µg/$248; 50 µg/$317

Select

Human c-Met Protein (Recombinant 6His, C-terminus) (Glu25-Thr932) - LS-G138719

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

102.5 kDa

Price:

10 µg/$248; 50 µg/$317

Select

Human c-Met Protein (Recombinant 6His, C-terminus) (Glu25-Gly519) - LS-G139091

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

56.9 kDa

Price:

10 µg/$281; 50 µg/$389

Select

Human c-Met Protein (Recombinant DDK (Flag)-His, C-terminus) - LS-G142205

Source:

HEK 293 Cells

Tag:

DDK (Flag)-His, C-terminus

Molecular Weight:

104 kDa

Price:

20 µg/$1,107

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Human c-Met Protein (Recombinant His-T7) (aa1092-1379) - LS-G24671

Source:

E. coli

Tag:

His-T7

Molecular Weight:

36.6 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Human c-Met Protein (Recombinant 6His, N-terminus) (Glu25-Thr932) - LS-G26961

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

45-150 kDa

Price:

10 µg/$289; 50 µg/$360; 100 µg/$432

Select

Mouse c-Met Protein (Recombinant His) (Met1-Asn929) - LS-G98218

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

102 kDa

Price:

100 µg/$661; 1 mg/$3,499

Select

Human c-Met Protein (Recombinant His) (Met1-Thr932) - LS-G97070

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

103 kDa

Price:

100 µg/$721; 1 mg/$4,701

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Human c-Met Protein (Recombinant His-GST) (Lys956-Ser1390) - LS-G97690

Source:

Baculovirus

Tag:

His-GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

76.8 kDa

Price:

50 µg/$707

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