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CALB2 / Calretinin

calbindin 2

Calbindin 2 (calretinin), closely related to calbindin 1, is an intracellular calcium-binding protein belonging to the troponin C superfamily. Calbindin 1 is known to be involved in the vitamin-D-dependent calcium absorption through intestinal and renal epithelia, while the function of neuronal calbindin 1 and calbindin 2 is poorly understood. The sequence of the calbindin 2 cDNA reveals an open reading frame of 271 codons coding for a protein of 31520 Da, and shares 58% identical residues with human calbindin 1. Calbindin 2 contains five presumably active and one presumably inactive calcium-binding domains. Comparison with the partial sequences available for chick and guinea pig calbindin 2 reveals that the protein is highly conserved in evolution. The calbindin 2 message was detected in the brain, while absent from heart muscle, kidney, liver, lung, spleen, stomach and thyroid gland. There are two additional forms of alternatively spliced calbindin 2 mRNAs encoding C-terminally truncated proteins. Exon 7 can splice to exon 9, resulting in a frame shift and a translational stop at the second codon of exon 9, and encoding calretinin-20k. Exon 7 can also splice to exon 10, resulting in a frame shift and a translational stop at codon 15 of exon 10, and encoding calretinin-22k. The truncated proteins are able to bind calcium.

Gene Name: calbindin 2
Synonyms: CALB2, 29 kDa calbindin, CAL2, Calretinin, CAB29, Calbindin 2, Calbindin D29K, CR
Target Sequences: NM_001740 NP_001731.2 P22676

Publications (1)

1
BAP1 haploinsufficiency predicts a distinct immunogenic class of malignant peritoneal mesothelioma. Shrestha R, Nabavi N, Lin YY, Mo F, Anderson S, Volik S, Adomat HH, Lin D, Xue H, Dong X, Shukin R, Bell RH, McConeghy B, Haegert A, Brahmbhatt S, Li E, Oo HZ, Hurtado-Coll A, Fazli L, Zhou J, McConnell Y, McCart A, Lowy A, Morin GB, Chen T, Daugaard M, Sahinalp SC, Hach F, Le Bihan S, Gleave ME, Wang Y, Churg A, Collins CC. Genome medicine. 2019 February;11:8. [Full Text Article] [PubMed:30777124] [PMC:PMC6378747]

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Products
ELISA Kits (21)
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CALB2 / Calretinin (21)
Human (6)
Mouse (3)
Rat (5)
Chicken (2)
Guinea pig (1)
Monkey (1)
Porcine (1)
Rabbit (1)
12 x 8-Well Microstrips (2)
96-Well Microplate (2)
96-Well Strip Plate (17)
No (21)
Cell Culture Supernatants (1)
Cell Lysates (1)
Plasma (11)
Serum (11)
Tissue Homogenates (4)
CALB2 / Calretinin ELISA Kit
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Sandwich
96-Well Microplate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
CALB2 / Calretinin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$764
CALB2 / Calretinin ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
CALB2 / Calretinin ELISA Kit
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Custom
96-Well Strip Plate
Chicken
Colorimetric - 450nm (TMB)
1 Plate/$783
CALB2 / Calretinin ELISA Kit
Select
Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$669
CALB2 / Calretinin ELISA Kit
Select
Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$669
CALB2 / Calretinin ELISA Kit
Select
Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$669
CALB2 / Calretinin ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
CALB2 / Calretinin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CALB2 / Calretinin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CALB2 / Calretinin ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
62.5 - 4000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
CALB2 / Calretinin ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Rat
0.156 - 10 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
CALB2 / Calretinin ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CALB2 / Calretinin ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
7.813 - 500 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
CALB2 / Calretinin ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
CALB2 / Calretinin ELISA Kit
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Sandwich
96-Well Strip Plate
Guinea pig
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
CALB2 / Calretinin ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
CALB2 / Calretinin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
7.813 - 500 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
CALB2 / Calretinin ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
25 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
CALB2 / Calretinin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
50 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
CALB2 / Calretinin ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).