CALB2 / Calretinin

calbindin 2

Calbindin 2 (calretinin), closely related to calbindin 1, is an intracellular calcium-binding protein belonging to the troponin C superfamily. Calbindin 1 is known to be involved in the vitamin-D-dependent calcium absorption through intestinal and renal epithelia, while the function of neuronal calbindin 1 and calbindin 2 is poorly understood. The sequence of the calbindin 2 cDNA reveals an open reading frame of 271 codons coding for a protein of 31520 Da, and shares 58% identical residues with human calbindin 1. Calbindin 2 contains five presumably active and one presumably inactive calcium-binding domains. Comparison with the partial sequences available for chick and guinea pig calbindin 2 reveals that the protein is highly conserved in evolution. The calbindin 2 message was detected in the brain, while absent from heart muscle, kidney, liver, lung, spleen, stomach and thyroid gland. There are two additional forms of alternatively spliced calbindin 2 mRNAs encoding C-terminally truncated proteins. Exon 7 can splice to exon 9, resulting in a frame shift and a translational stop at the second codon of exon 9, and encoding calretinin-20k. Exon 7 can also splice to exon 10, resulting in a frame shift and a translational stop at codon 15 of exon 10, and encoding calretinin-22k. The truncated proteins are able to bind calcium.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

CALB2 / Calretinin (8)

Publications

No (8)

Tag

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

His (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (7)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human CALB2 / Calretinin Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65145

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

31.4 kDa

Price:

20 µg/$1,107

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Human CALB2 / Calretinin Protein (Recombinant 6His, N-terminus) (Full Length) - LS-G26358

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

27 kDa

Price:

10 µg/$265; 50 µg/$315; 100 µg/$365

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Human CALB2 / Calretinin Protein (Recombinant GST, N-terminus) (aa172-271) - LS-G57964

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CALB2 / Calretinin Protein (Recombinant His-T7) (aa28-248) - LS-G12629

Source:

E. coli

Tag:

His-T7

Molecular Weight:

29.7 kDa

Price:

50 µg/$402; 10 µg/$275; 200 µg/$802; 100 µg/$642; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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Human CALB2 / Calretinin Protein (Recombinant GST) (Full Length) - LS-G27715

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

47.1 kDa

Price:

10 µg/$479; 25 µg/$670

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Human CALB2 / Calretinin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74948

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

31.4 kDa

Price:

20 µg/$150

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CALB2 / Calretinin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99544

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

31.4 kDa

Price:

100 µg/$494

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Human CALB2 / Calretinin Protein (Recombinant His) - LS-G918

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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