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CASP1 / Caspase 1

caspase 1, apoptosis-related cysteine peptidase

CASP1 / Caspase 1 is a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.

Gene Name: caspase 1, apoptosis-related cysteine peptidase
Family/Subfamily: Protease , Cysteine C14
Synonyms: CASP1, Caspase-1, CASP-1, CASP1 nirs variant 1, Caspase 1, ICE, ICE-like protease, IL-1 beta-converting enzyme, IL-1BC, IL1BC, IL1BCE, p45, IL1B-convertase, Interleukin-1 beta convertase
Target Sequences: NM_001223 NP_001214.1 P29466

Publications (1)

1
Pentoxifylline prevents epileptic seizure via modulating HMGB1/RAGE/TLR4 signalling pathway and improves memory in pentylenetetrazol kindling rats. Ghada A Badawi, Mustafa M Shokr, Hala F Zaki, Ahmed F Mohamed. Clinical and experimental pharmacology & physiology. 2021 August;48:1111-1124. [Full Text Article] [PubMed:33899956]

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Antibodies (115)
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CASP1 / Caspase 1 Antibody - Anti-Caspase 1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
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CASP1 / Caspase 1 Mouse anti-Human Monoclonal (aa371-390) (14F468) Antibody
Mouse, Human
ICC, IHC, IHC-P, WB
Unconjugated
50 µg/$460
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CASP1 / Caspase 1 Rat anti-Mouse Monoclonal (aa206-220) (1H11) Antibody
Mouse
ELISA, Flo, WB
Unconjugated
100 µg/$755
CASP1 / Caspase 1 Antibody - CASP1 / Caspase 1 antibody. IHC(P): Human Breast Cancer Tissue.
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CASP1 / Caspase 1 Rabbit anti-Human Polyclonal (aa249-262) Antibody
Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
CASP1 / Caspase 1 Antibody - Western blot of Cleaved-Caspase-1 (D210) antibody
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CASP1 / Caspase 1 Rabbit anti-Human Polyclonal (130-210 aa, Internal) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CASP1 / Caspase 1 Antibody - Western blot of recombinant CASP1 / Caspase 1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CASP1 / Caspase 1 Rabbit anti-Pig Polyclonal (aa120-297) Antibody
Pig, Human
ICC, IP, WB
Unconjugated
100 µl/$323; 200 µl/$371; 500 µl/$531; 1 ml/$617; 2 ml/$850; 5 ml/$1,401
CASP1 / Caspase 1 Antibody - Western blot of recombinant CASP1 / Caspase 1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CASP1 / Caspase 1 Rabbit anti-Pig Polyclonal (aa120-297) (Biotin) Antibody
Pig, Human
WB
Biotin Conjugated
100 µl/$334; 200 µl/$387; 500 µl/$563; 1 ml/$678; 2 ml/$915; 5 ml/$1,541
CASP1 / Caspase 1 Antibody - CASP1 / Caspase 1 antibody Western blot of 721_B cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CASP1 / Caspase 1 Rabbit anti-Human Polyclonal (aa30-79) (Biotin) Antibody
Horse, Human
WB
Biotin Conjugated
100 µl/$469
CASP1 / Caspase 1 Antibody
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CASP1 / Caspase 1 Rabbit anti-Human Polyclonal (aa120-297) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$313; 200 µl/$357; 500 µl/$503; 1 ml/$576; 2 ml/$788; 5 ml/$1,279
CASP1 / Caspase 1 Antibody
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CASP1 / Caspase 1 Rabbit anti-Human Polyclonal (aa317-404) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$313; 200 µl/$357; 500 µl/$503; 1 ml/$576; 2 ml/$788; 5 ml/$1,279
CASP1 / Caspase 1 Antibody - Western blot of CASP1 expression in transfected 293T cell line by CASP1 monoclonal antibody (M01), clone 3D2.
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CASP1 / Caspase 1 Mouse anti-Human Monoclonal (3D2) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
CASP1 / Caspase 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Ascites, Cell Culture Supernatants, Cerebrospinal Fluid, Plasma, Saliva, Serum, Tissue Homogenates, Urine
1 Plate/$585
CASP1 / Caspase 1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CASP1 / Caspase 1 Protein - 12.5% SDS-PAGE of human CASP1 stained with Coomassie Blue
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Wheat Germ Extract
GST
61.4 kDa
2 µg/$439
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HEK 293 Cells
Myc-DDK (Flag)
29.6 kDa
20 µg/$1,107
CASP1 / Caspase 1 Antibody - Anti-Caspase 1 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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CASP1 / Caspase 1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
CASP1 / Caspase 1 ELISA Kit
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Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
CASP1 / Caspase 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Dog
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
CASP1 / Caspase 1 Protein - Recombinant Caspase 1 By SDS-PAGE
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E. coli
His, N-Terminal
21.6 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
CASP1 / Caspase 1 Antibody - Anti-Caspase 1 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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CASP1 / Caspase 1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
CASP1 / Caspase 1 Protein - Active Caspase 1 (CASP1) by WB
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E. coli
His, N-Terminal
21kDa
10 µg/$370; 50 µg/$922; 200 µg/$1,577; 100 µg/$1,345; 1 mg/$2,945; 500 µg/$2,397; 5 mg/$6,441; 2 mg/$3,436
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CASP1 / Caspase 1 Rabbit anti-Human Polyclonal (aa225-242) Antibody
Mouse, Rat, Human
ICC, IP, WB
Unconjugated
100 µg/$854
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CASP1 / Caspase 1 Rabbit anti-Human Polyclonal (170-250 aa, Internal) Antibody
Human
ELISA, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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CASP1 / Caspase 1 Rabbit anti-Insect Polyclonal (N-Terminus) Antibody
ELISA, WB
Unconjugated
0.1 mg/$379
CASP1 / Caspase 1 Antibody - Caspase-1(P20) antibody Western blot. Lane 1: Rat Brain Tissue Lysate. Lane 2: Rat Spleen Tissue Lysate. Lane 3: Mouse Brain Tissue Lysate. Lane 4: Mouse Spleen Tissue Lysate. Lane 5: Mouse Testis Tissue Lysate.
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CASP1 / Caspase 1 Rabbit anti-Mouse Polyclonal (aa137-157) Antibody
Mouse, Rat
WB
Unconjugated
10 µg/$318; 100 µg/$470
CASP1 / Caspase 1 Antibody - Western blot of recombinant CASP1 / Caspase 1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CASP1 / Caspase 1 Rabbit anti-Rat Polyclonal (aa119-296) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$312; 200 µl/$355; 500 µl/$500; 1 ml/$573; 2 ml/$780; 5 ml/$1,268
Viewing 1-25 of 160 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).