CASP8 / Caspase 8

caspase 8, apoptosis-related cysteine peptidase

Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.

☰ Filters

Products

ELISA Kits (29)

Type

Cell-Based (1)

Cell-Based Phosphorylation (2)

Custom (2)

Development Kit (2)

Sandwich (19)

Sandwich CLIA (3)

Target

CASP8 / Caspase 8 (29)

Reactivity

Human (15)

Mouse (7)

Rat (8)

Canine (1)

Pig (1)

Product Group

DevKit DuoPlus (2)

Format

12 x 8-Well Microstrips (3)

96-Well Microplate (7)

96-Well Strip Plate (17)

Antibody Pair and Standard (2)

Publications

No (29)

Sample Type

Adherent Cell Cultures (3)

Cell Culture Supernatants (6)

Cell Lysates (6)

Plasma (17)

Serum (19)

Tissue Homogenates (12)

Select

Human CASP8 / Caspase 8 (Sandwich ELISA) ELISA Kit - LS-F11021

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$585

Select

Mouse CASP8 / Caspase 8 (Sandwich ELISA) ELISA Kit - LS-F11020

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

Select

Mouse/Human/Rat CASP8 / Caspase 8 (Cell-Based ELISA) ELISA Kit - LS-F1856

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$534

Select

Human CASP8 / Caspase 8 (Sandwich ELISA) ELISA Kit - LS-F5366

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Tissue Homogenates

Price:

1 Plate/$685

Select

Human CASP8 / Caspase 8 (Sandwich ELISA) ELISA Kit - LS-F51599

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

31.25 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Plasma, Serum

Price:

1 Plate/$1,041

Select

Rat CASP8 / Caspase 8 (Sandwich ELISA) ELISA Kit - LS-F4274

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$741

Select

Human/Rat Phospho-CASP8 / Caspase 8 (Ser347) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1076

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

Select

Rat CASP8 / Caspase 8 (CLIA) ELISA Kit - LS-F37510

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Rat

Range:

31.25 - 2000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

Select

Human CASP8 / Caspase 8 (Sandwich ELISA) ELISA Kit - LS-F31624

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

31.2 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Serum, Tissue Homogenates

Price:

1 Plate/$624

Select

Human CASP8 / Caspase 8 (CLIA) ELISA Kit - LS-F29519

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

31.25 - 2000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

Select

Mouse CASP8 / Caspase 8 (CLIA) ELISA Kit - LS-F30456

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse

Range:

31.25 - 2000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

Select

Human CASP8 / Caspase 8 (Sandwich ELISA) ELISA Kit - LS-F32783

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Rat CASP8 / Caspase 8 (Sandwich ELISA) ELISA Kit - LS-F32784

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Mouse CASP8 / Caspase 8 (Sandwich ELISA) ELISA Kit - LS-F32785

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Pig CASP8 / Caspase 8 (Sandwich ELISA) ELISA Kit - LS-F32786

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Pig

Range:

78.125 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human CASP8 / Caspase 8 (Custom ELISA) ELISA Kit - LS-F50241

Type:

Custom

Format:

96-Well Microplate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$635

Select

Human CASP8 / Caspase 8 (Sandwich ELISA) ELISA Kit - LS-F39693

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

31.2 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Serum

Price:

1 Plate/$901

Select

DevKit DuoPlus Human CASP8 / Caspase 8 ELISA Development Kit - LS-F71472

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Human

Range:

1.25 - 80 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Tissue Homogenates

Price:

500 Wells/$1,089; 1000 Wells/$1,589

Select

DevKit DuoPlus Mouse CASP8 / Caspase 8 ELISA Development Kit - LS-F71489

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Mouse

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Tissue Homogenates

Price:

500 Wells/$1,109; 1000 Wells/$1,625

Select

Canine CASP8 / Caspase 8 (Sandwich ELISA) ELISA Kit - LS-F56402

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Canine

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human CASP8 / Caspase 8 (Sandwich ELISA) ELISA Kit - LS-F56377

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

31.2 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Rat CASP8 / Caspase 8 (Custom) ELISA Kit - LS-F66170

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Price:

1 Plate/$669

Select

Mouse CASP8 / Caspase 8 (Sandwich ELISA) ELISA Kit - LS-F21298

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

Select

Rat CASP8 / Caspase 8 (Sandwich ELISA) ELISA Kit - LS-F21520

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

Select

Human CASP8 / Caspase 8 (Sandwich ELISA) ELISA Kit - LS-F20970

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

Viewing 1-25 of 29 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: ELISA Kits

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.