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CCL21 / SLC

chemokine (C-C motif) ligand 21

This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19).

Gene Name: chemokine (C-C motif) ligand 21
Family/Subfamily: Intercrine , Intercrine beta
Synonyms: CCL21, 6Ckine, Beta chemokine exodus-2, C-C motif chemokine 21, Beta-chemokine exodus-2, CKb9, ECL, Small-inducible cytokine A21, SCYA21, SLC, Exodus-2, TCA4
Target Sequences: NM_002989 NP_002980.1 O00585

Publications (4)

1
Integrated pharmacokinetic, pharmacodynamic and immunogenicity profiling of an anti-CCL21 monoclonal antibody in cynomolgus monkeys. Dudal S, Subramanian K, Flandre T, Law WS, Lowe PJ, Skerjanec A, Genin JC, Duval M, Piequet A, Cordier A, Jarai G, Van Heeke G, Taplin S, Krantz C, Jones S, Warren AP, Brennan FR, Sims J, Lloyd P. mAbs. 2015 7:829-37. (WB; Human) [Full Text Article] [PubMed:26230385] [PMC:PMC4622749] Related Antibodies: LS-C104622.
2
Renal allograft rejection, lymphocyte infiltration, and de novo donor-specific antibodies in a novel model of non-adherence to immunosuppressive therapy. Kühne L, Jung B, Poth H, Schuster A, Wurm S, Ruemmele P, Banas B, Bergler T. BMC immunology. 2017 December;18:52. (Mouse) [Full Text Article] [PubMed:29258420] [PMC:PMC5735914]
3
CD8+ T cell immunity blocks the metastasis of carcinogen-exposed breast cancer. Kaiwen Li, Tiancheng Li, Zhaoyi Feng, Mei Huang, Lei Wei, Zhiyu Yan, Mark Long, Qiang Hu, Jianmin Wang, Song Liu, Dennis C Sgroi, Shadmehr Demehri. Science advances. 2021 June;7: [Full Text Article] [PubMed:34144976] [PMC:PMC8213232]
4
Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells. Beth Lucas, Andrea J White, Emilie J Cosway, Sonia M Parnell, Kieran D James, Nick D Jones, Izumi Ohigashi, Yousuke Takahama, William E Jenkinson, Graham Anderson. Nature communications. 2020 May;11:2198. [Full Text Article] [PubMed:32366944] [PMC:PMC7198500] Related Antibodies: LS-C104634.
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CCL21 / SLC (25)
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CCL21 / SLC ELISA Kit
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Sandwich
96-Well Microplate
Mouse
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
CCL21 / SLC ELISA Kit
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Sandwich
96-Well Microplate
Rat
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
CCL21 / SLC ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
7.8 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$715
CCL21 / SLC ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$656
CCL21 / SLC ELISA Kit
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Sandwich
96-Well Strip Plate
Human
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CCL21 / SLC ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CCL21 / SLC ELISA Kit
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Sandwich
96-Well Microplate
Human
30 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
CCL21 / SLC ELISA Kit
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Sandwich
96-Well Microplate
Mouse
15.63 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
CCL21 / SLC ELISA Kit
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Sandwich
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$798
CCL21 / SLC ELISA Kit
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Sandwich
96-Well Microplate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$699
CCL21 / SLC ELISA Kit
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Custom
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$968
CCL21 / SLC ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$585
CCL21 / SLC ELISA Kit
Select
Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$585
CCL21 / SLC ELISA Kit
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Sandwich
96-Well Microplate
Human
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
CCL21 / SLC ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$582
CCL21 / SLC ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$582
CCL21 / SLC ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CCL21 / SLC ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Rat
15.625 - 1000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
CCL21 / SLC ELISA Kit
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Sandwich
96-Well Strip Plate
Human
5 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
CCL21 / SLC ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
50 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
CCL21 / SLC ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Mouse
7.813 - 500 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
CCL21 / SLC ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
100 - 2500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
CCL21 / SLC ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
CCL21 / SLC ELISA Kit
Select
Development Kit
1000 Wells
Mouse
16 - 1000 pg/ml
Colorimetric - 405nm (ABTS)
1 Test/$540
CCL21 / SLC ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum
1 Plate/$699
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).