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Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
Gene Name: | chemokine (C-C motif) ligand 25 |
Family/Subfamily: | Intercrine , Intercrine beta |
Synonyms: | CCL25, C-C motif chemokine 25, Ck beta-15, TECK, Thymus-expressed chemokine, Small-inducible cytokine A25, TECKvar, Chemokine TECK, Ckb15, SCYA25, Thymus expressed chemokine |
Target Sequences: | NM_005624 NP_005615.2 O15444 |
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