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CCL27 is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation.
Gene Name: | chemokine (C-C motif) ligand 27 |
Family/Subfamily: | Intercrine , Intercrine beta |
Synonyms: | CCL27, ALP, Chemokine alp, C-C motif chemokine 27, CC chemokine ILC, CTAK, ESKINE, IL-11 R-alpha-locus chemokine, ILC, IL-11 Ralpha-locus chemokine, PESKY, SCYA27, Skinkine, CTACK, Il-11r alpha-locus chemokine, Small-inducible cytokine A27 |
Target Sequences: | NM_006664 NP_006655.1 Q9Y4X3 |
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