CCL5 / RANTES

chemokine (C-C motif) ligand 5

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:16791620, PubMed:1380064, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485).

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Proteins (36)

Type

Over-Expression Lysate (2)

Recombinant (32)

Target

CCL5 / RANTES (36)

Format

Animal-free (1)

Publications

No (36)

Tag

6His, N-terminus (3)

GST (2)

His (7)

His-GST (2)

His-S (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Bovine (1)

Dog (1)

Guinea pig (1)

Horse (1)

Human (22)

Mouse (4)

Pig (1)

Rat (3)

Rhesus monkey (1)

Source

293T Cells (1)

E. coli (30)

HEK 293 Cells (3)

Wheat Germ Extract (1)

Purification

Purified (15)

Low Endotoxin Level

Low endotoxin level (18)

Biologically Active

Biologically active (11)

Animal-free

Animal-free (1)

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Rhesus monkey CCL5 / RANTES Protein (Recombinant His) (aa24-91) - LS-G11596

Source:

E. coli

Tag:

His

Molecular Weight:

9.3 kDa

Price:

10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284

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Human CCL5 / RANTES Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71192

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

7.8 kDa

Price:

20 µg/$1,107

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Human CCL5 / RANTES Protein (Recombinant 6His, N-terminus) (Ser24-Ser91) - LS-G26578

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

10 kDa

Price:

10 µg/$265; 50 µg/$315; 100 µg/$365

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Human CCL5 / RANTES Protein (Recombinant) - LS-G256

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

7.8 kDa

Price:

5 µg/$268; 20 µg/$349

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Human CCL5 / RANTES Protein (Recombinant) - LS-G3674

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).

Price:

5 µg/$282; 20 µg/$370

• Unmodified
• Animal-free

• Unmodified
• Animal-free

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Rat CCL5 / RANTES Protein (Recombinant) - LS-G401

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

7.9 kDa

Price:

5 µg/$268; 20 µg/$349

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Human CCL5 / RANTES Protein (Recombinant His) (aa24-91) - LS-G4109

Source:

E. coli

Tag:

His

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Price:

50 µg/$621

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Mouse CCL5 / RANTES Protein (Recombinant) - LS-G216

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

7.8 kDa

Price:

5 µg/$268; 20 µg/$349

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Human CCL5 / RANTES Protein (Recombinant) (aa24-91) - LS-G5631

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Molecular Weight:

7.8 kDa

Price:

5 µg/$282; 100 µg/$957; 500 µg/$1,747

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Mouse CCL5 / RANTES Protein (Recombinant) (aa24-91) - LS-G5671

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Molecular Weight:

7.9 kDa

Price:

5 µg/$282; 100 µg/$957; 500 µg/$1,747

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Bovine CCL5 / RANTES Protein (Recombinant His) (Ser24-Ser91) - LS-G11591

Source:

E. coli

Tag:

His

Molecular Weight:

9.4 kDa

Price:

10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900

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Human CCL5 / RANTES Protein (Recombinant His-T7) (aa24-91) - LS-G11592

Source:

E. coli

Tag:

His-T7

Molecular Weight:

11.7 kDa

Price:

10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998

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Guinea pig CCL5 / RANTES Protein (Recombinant His-GST) (aa24-91) - LS-G11593

Source:

E. coli

Tag:

His-GST

Molecular Weight:

40.3 kDa

Price:

10 µg/$289; 50 µg/$490; 100 µg/$782; 200 µg/$977; 1 mg/$2,114; 500 µg/$1,640; 5 mg/$3,417; 2 mg/$2,304

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Dog CCL5 / RANTES Protein (Recombinant His-S) (aa24-91) - LS-G11594

Source:

E. coli

Tag:

His-S

Molecular Weight:

13.6 kDa

Price:

10 µg/$292; 50 µg/$512; 100 µg/$817; 200 µg/$1,018; 1 mg/$2,168; 500 µg/$1,690; 5 mg/$3,571; 2 mg/$2,359

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Mouse CCL5 / RANTES Protein (Recombinant His-GST) (aa24-91) - LS-G11595

Source:

E. coli

Tag:

His-GST

Molecular Weight:

40.3 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Human CCL5 / RANTES Protein (Recombinant GST) (aa24-91) - LS-G22297

Source:

E. coli

Tag:

GST

Molecular Weight:

35.2 kD

Price:

100 µg/$420; 20 µg/$323

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Human CCL5 / RANTES Protein (Recombinant His) (aa24-91) - LS-G22298

Source:

E. coli

Tag:

His

Molecular Weight:

11.9 kD

Price:

100 µg/$420; 20 µg/$323

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Horse CCL5 / RANTES Protein (Recombinant His) (aa24-91) - LS-G23917

Source:

E. coli

Tag:

His

Molecular Weight:

11.6 kDa

Price:

10 µg/$290; 50 µg/$500; 100 µg/$797; 200 µg/$997; 1 mg/$2,139; 500 µg/$1,662; 5 mg/$3,487; 2 mg/$2,329

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Pig CCL5 / RANTES Protein (Recombinant His) (aa24-91) - LS-G23918

Source:

E. coli

Tag:

His

Molecular Weight:

11.6 kDa

Price:

10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284

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Human CCL5 / RANTES Protein (Recombinant) - LS-G37703

Tag:

None

Molecular Weight:

7.8 kD

Price:

20 µg/$484

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Human CCL5 / RANTES Protein (Recombinant) - LS-G27273

Source:

HEK 293 Cells

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.2 EU/µg protein (determined by LAL method).

Molecular Weight:

8 kDa (SDS-PAGE)

Price:

5 µg/$253; 25 µg/$296

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Human CCL5 / RANTES Protein (Recombinant GST) (Full Length) - LS-G30340

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

35.75 kDa

Price:

10 µg/$479; 25 µg/$670

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Human CCL5 / RANTES Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89156

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

9.99 kDa

Price:

20 µg/$150

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CCL5 / RANTES Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99928

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

9.99 kDa

Price:

100 µg/$494

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Mouse CCL5 / RANTES Protein (Recombinant) - LS-G137764

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.01 ng/µg (determined by LAL method).

Molecular Weight:

The 68 amino acid recombinant protein has a predicted molecular mass of approximately 7.8 kD. The DTT-reduced protein migrates at approximately 10 kD and non-reduced protein migrates at approximately 11 kD by SDS-PAGE. The predicted N-terminal amino acid

Price:

10 µg/$283; 25 µg/$359; 100 µg/$620

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