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CCR2

chemokine (C-C motif) receptor 2

CCR2, a Chemokine Receptor, is a regulator of monocyte/macrophage trafficking and is upregulated in response to inflammation. Resistance to HIV-1 infection or delayed progression to AIDS may be linked to CCR2 polymorphisms. The ligand for CCR2 is monocyte chemoattractant protein (MCP-1), a chemokine produced by endothelial cells, smooth muscle cells, and macrophages. Activation of monocytes by MCP-1 may mediate the monocytic infiltration of tissues in atherosclerosis (Boring et al., 1998) and other inflammatory disorders including rheumatoid arthritis, alveolitis, and tumor infiltration. Two isoforms are produced by alternative splicing.

Gene Name: chemokine (C-C motif) receptor 2
Family/Subfamily: GPCR , Chemokine
Synonyms: CCR2, C-C chemokine receptor type 2, CD192, Cc chemokine receptor 2, CCR-2, CCR2A, C-C CKR-2, CKR2, CD192 antigen, CKR2A, CKR2B, Mcp1 receptor, MCP-1 receptor, MCP-1-R, C-c chemokine receptor 2, CC-CKR-2, Cc-ckr2, CCR2B, CMKBR2, Mcp1r
Target Sequences: NP_001116868.1 P41597

Publications (1)

1
Interleukin-17 potently increases non-small cell lung cancer growth. Wei L, Wang H, Yang F, Ding Q, Zhao J. Molecular medicine reports. 2016 13:1673-80. (Flo; Mouse) [Full Text Article] [PubMed:26708832] Related Antibodies: LS-C127284.

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Antibodies (54)
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rabbit (43)
mouse (8)
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CCR2 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CCR2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
CCR2 Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CCR2 Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
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CCR2 Rat anti-Mouse Monoclonal (APC) (475301) Antibody
Mouse, Rat
Flo
APC Conjugated
100 Tests/$907
CCR2 Antibody - Clone 7A7 human tonsil paraffin section
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CCR2 Mouse anti-Human Monoclonal (7A7) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated
200 µg/$672
CCR2 Antibody - Western blot analysis of Mouse skin tissue, using CCR2 Polyclonal Antibody at dilution of 1:450.
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CCR2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
CCR2 Antibody - CCR2 Antibody - Immunocytochemical analysis of CCR2 in NIH/3T3 cells.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CCR2 Rabbit anti-Mouse Polyclonal (aa20-100) Antibody
Mouse, Human
Flo, ICC
Unconjugated
0.1 ml/$386
CCR2 Antibody - CCR2 Antibody - Immunocytochemical analysis of CCR2 in NIH/3T3 cells.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CCR2 Rabbit anti-Mouse Polyclonal (aa20-100) (Biotin) Antibody
Mouse, Human
Flo, ICC, WB
Biotin Conjugated
0.1 ml/$416
CCR2 Antibody - CCR2 Antibody - Immunocytochemical analysis of CCR2 in NIH/3T3 cells.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CCR2 Rabbit anti-Mouse Polyclonal (aa20-100) (DY650) Antibody
Mouse, Human
Flo, ICC, WB
DY650 Conjugated
0.1 ml/$416
CCR2 Antibody - CCR2 Antibody - Immunocytochemical analysis of CCR2 in NIH/3T3 cells.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CCR2 Rabbit anti-Mouse Polyclonal (aa20-100) (DY488) Antibody
Mouse, Human
Flo, ICC, WB
DY488 Conjugated
0.1 ml/$416
CCR2 Antibody - CCR2 Antibody - Immunocytochemical analysis of CCR2 in NIH/3T3 cells.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CCR2 Rabbit anti-Mouse Polyclonal (aa20-100) (DY550) Antibody
Mouse, Human
Flo, ICC, WB
DY550 Conjugated
0.1 ml/$416
CCR2 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
CCR2 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$764
CCR2 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$782
CCR2 Antibody - Western blot analysis using CD192 mAb against HEK293 (1) and CD192-hIgGFc transfected HEK293 (2) cell lysate.
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CCR2 Mouse anti-Human Monoclonal (3B6B1) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µg/$459
CCR2 Antibody - Anti-CD192 rabbit polyclonal antibody at 1:500 dilution. Lane A: A431 Membrane Lysate. Lysates/proteins at 30 ug per lane. Secondary: Goat Anti-Rabbit IgG H&L (Dylight 800) at 1/10000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size: 42 kDa. Observed band size: 55 kDa. (We are unsure as to the identity of these extra bands.)
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CCR2 Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ICC, IF, WB
Unconjugated, Preservative Free
100 µl/$412
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CCR2 Goat anti-Human Polyclonal Antibody
Human
ELISA, ICC, WB
Unconjugated
200 µg/$536
CCR2 Antibody - 1:100 staining human liver carcinoma tissues by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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CCR2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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CCR2 Mouse anti-Human Monoclonal (Preservative Free) (02) Antibody
Human
Flo
Unconjugated, Preservative Free
100 µl/$412
CCR2 Antibody - Western blot analysis of extracts of various cells.
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CCR2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
CCR2 Antibody - Western blot of lysate from THP-1 cell line with CCR2 Antibody. Antibody was diluted at 1:1000. A goat anti-rabbit IgG H&L (HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20 ug.
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CCR2 Rabbit anti-Human Polyclonal (aa336-369) Antibody
Human
WB
Unconjugated
400 µl/$393
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CCR2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µg/$331
CCR2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
41.7 kDa
20 µg/$150
CCR2 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
23.44 - 1500 pg/ml
Colorimetric - 450nm (TMB)
Cerebrospinal Fluid, Plasma, Serum, Tissue Homogenates
1 Plate/$968
CCR2 Antibody - CCR2 Antibody - Immunocytochemical analysis of CCR2 in HeLa cells.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CCR2 Rabbit anti-Human Polyclonal (aa20-100) Antibody
Rat, Human
Flo, ICC, WB
Unconjugated
0.1 ml/$386
CCR2 Antibody - CCR2 Antibody - Immunocytochemical analysis of CCR2 in HeLa cells.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CCR2 Rabbit anti-Human Polyclonal (aa20-100) (Biotin) Antibody
Rat, Human
Flo, ICC, WB
Biotin Conjugated
0.1 ml/$416
Viewing 1-25 of 73 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).