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CCR4
chemokine (C-C motif) receptor 4
High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
| Gene Name: | chemokine (C-C motif) receptor 4 |
| Family/Subfamily: | GPCR , Chemokine |
| Synonyms: | CCR4, C-C chemokine receptor type 4, CD194, CD194 antigen, C-C CKR-4, Chemr13, CKR-4, CC chemokine receptor 4, CC-CKR-4, CCR-4, HGCN:14099, C-c chemokine receptor 4, Chemokine (C-C) receptor 4, CKR4, CMKBR4, K5-5 |
| Target Sequences: | NM_005508 NP_005499.1 P51679 |
Publications (3)
1
Aberrant CCR4 expression is involved in tumor invasion of lymph node-negative human gastric cancer. Yang Y, Du L, Yang X, Qu A, Zhang X, Zhou C, Wang C. PloS one. 2015 10:e0120059. (IHC; Human)
[Full Text Article]
[PubMed:25790118]
[PMC:PMC4366399]
Related Antibodies: LS-A351.
2
CCR4 Expression Is Associated With Poor Prognosis in Patients With Early Stage (pN0) Oral Tongue Cancer. Lei Wang, Mei Zhang, Yuntao Zhu, Xin Zhang, Yongmei Yang, Chuanxin Wang. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons. 2019 Feb;77:426-432. [Full Text Article]
[PubMed:30395826]
Related Antibodies: LS-A351.
3
Aberrant expression of chemokine receptor CCR4 in human gastric cancer contributes to tumor-induced immunosuppression. Yang YM, Feng AL, Zhou CJ, Liang XH, Mao HT, Deng BP, Yan S, Sun JT, Du LT, Liu J, Wang QJ, Neckenig MR, Yang QF, Qu X. Cancer science. 2011 Jul;102:1264-71. [Full Text Article]
[PubMed:21443538]
Related Antibodies: LS-A351.
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Neuroscience
CCR4 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
Fast Shipping
CCR4 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
Neuroscience
Fast Shipping
CCR4 Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Human, Monkey
ELISA, IHC, IHC-P
Unconjugated
50 µg/$440
Neuroscience
Fast Shipping
CCR4 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$460
CCR4 Goat anti-Human Polyclonal (Extracellular Domain) Antibody
Human, Monkey
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
50 µg/$515
CCR4 Rabbit anti-Mouse Polyclonal (aa8-26) Antibody
Mouse
ELISA, Flo, IHC, IHC-Fr, WB
Unconjugated
50 µl/$786
CCR4 Goat anti-Mouse Polyclonal (aa8-26) Antibody
Mouse
ELISA, Flo, IHC, WB
Unconjugated
100 µg/$649; 200 µg/$890
Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
E. coli
10His, N-terminus
44.9 kDa
100 µg/$1,293; 20 µg/$854
CCR4 Rabbit anti-Human Polyclonal (aa211-260) Antibody
Mouse, Rat, Human
IF, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
CCR4 Mouse anti-Human Monoclonal (FITC) (11D79) Antibody
Rat, Human
Flo
FITC Conjugated
100 Tests/$774
CCR4 Rabbit anti-Human Polyclonal (aa1-48) Antibody
Mouse, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CCR4 Rabbit anti-Human Polyclonal (aa262-290) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
CCR4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CCR4 Mouse anti-Human Monoclonal (PE) (11D81) Antibody
Human
Flo
PE Conjugated
100 Tests/$906
CCR4 Rabbit anti-Human Polyclonal (aa180-229) Antibody
Human
WB
Unconjugated
100 µl/$424
CCR4 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
10 µg/$318; 100 µg/$470
CCR4 Goat anti-Mouse Polyclonal (aa8-26) Antibody
Mouse
ELISA, Flo, IHC, WB
Unconjugated
100 µg/$556
CCR4 Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, Flo, IHC-Fr, WB
Unconjugated
50 µl/$500
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$764
CCR4 Goat anti-Human Polyclonal (aa17-39) Antibody
Human
ELISA, Flo, IHC-Fr, IHC-P, WB
Unconjugated
0.1 mg/$500
CCR4 Rabbit anti-Human Polyclonal (180-260 aa, Internal) Antibody
Mouse, Rat, Human
ELISA, IF
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CCR4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF
Unconjugated
100 µg/$357
CCR4 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ELISA, WB
Unconjugated
40 µg/$485
CCR4 Rabbit anti-Human Polyclonal (1-50 aa, N-terminal) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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